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Dasabuvir
go.drugbank.com/drugs/DB09183ApprovedThe binding sites for non-nucleoside NS5B inhibitors are poorly conserved across HCV genotypes leading to the restriction of Dasabuvir's use to genotype 1 only. … When combined together, Dasabuvir [DB09296], [DB09297], and [DB00503] as the combination product Viekira Pak have been shown to achieve a SVR of 100% for genotype 1b and 89% or 95% for genotype 1a after
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseHexaminolevulinate
go.drugbank.com/drugs/DB06261ApprovedInvestigationalIn solution form it is instilled intravesically for use with photodynamic blue light cystoscopy as an adjunct to white light cystoscopy. On May 28, 2010, the U.S. … Karl Storz Photodynamic Diagnostic D-Light C (PDD) System for cystoscopic detection of non-muscle invasive papillary cancer of the bladder for patients suspected or known to have lesion(s) on the basis
Chronic Myelogenous Leukemia (CML)
go.drugbank.com/conditions/DBCOND0040386Synonyms: Chronic myelogenous leukemia, no International Classification of Diseases for Oncology subtypeBisoprolol
go.drugbank.com/drugs/DB00612ApprovedInvestigational[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. … It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.
Categories: Antihypertensive Agents Indicated for HypertensionProducts: CONCOR COR 5MG, CONCOR COR 10MGBrotizolam
go.drugbank.com/drugs/DB09017ApprovedWithdrawnBrotizolam is not approved for sale in the UK, United States or Canada but is sold in the Netherlands, Germany, Spain, Belgium, Austria, Portugal, Israel, Italy and Japan. … Brotizolam has similar effects to short-acting benzodiazepines such as triazolam. Brotizolam is indicated for 2-4 weeks of treatment for severe or debilitating insomnia.
Amoxapine
go.drugbank.com/drugs/DB00543ApprovedIn non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation. In depressed individuals, amoxapine exerts a positive effect on mood. … See toxicity section below for a complete listing of side effects.
Categories: Antidepressive Agents Indicated for Depression, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeEstradiol valerate
go.drugbank.com/drugs/DB13956ApprovedInvestigationalVet approveddue to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure, and for the treatment of advanced androgen-dependent carcinoma of the prostate (for palliation … As a pro-drug of estradiol, estradiol acetate therefore has the same downstream effects within the body through binding to the Estrogen Receptor (ER) including ERα and ERβ subtypes, which are located in
Categories: Hormonal Contraceptives for Systemic UseLisdexamfetamine
go.drugbank.com/drugs/DB01255ApprovedInvestigational[L48285] Lisdexamfetamine works to treat attention deficit hyperactivity disorder and binge eating disorder [A2230] by blocking dopamine and norepinephrine reuptake and increasing their levels in the extraneuronal … Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine,[A40246] covalently attached to the naturally occurring amino acid L-lysine.
Categories: Psychostimulants, Agents Used for ADHD and Nootropics, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromePlant-based virus-like particles, recombinant, adjuvanted COVID-19 vaccine
go.drugbank.com/drugs/DB16757Approvedfor the prevention of COVID-19. … [A245824] In addition, VLPs contain no viral material and are therefore inherently non-infectious, making them potentially safer alternatives to traditional vaccines.[A245824]
Siponimod
go.drugbank.com/drugs/DB12371ApprovedInvestigationalSymptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. … Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS).