Search
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
go.drugbank.com/bio_entities/BE0000525TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371).
Synonyms: Complex I-B16.6Velmanase alfa
go.drugbank.com/drugs/DB12374ApprovedInvestigationalPatients with alpha-mannosidosis have a genetic mutation that causes a deficiency in the lysosomal enzyme alpha-mannosidase, which is an enzyme responsible for breaking down complex sugars in the body. … [L39744] It was granted marketing authorization by the European Commission in March 2018 under the market name Lamzede [L39754] as the first human recombinant form of alpha-mannosidase for the treatment
Palbociclib
go.drugbank.com/drugs/DB09073ApprovedInvestigationalPalbociclib is a piperazine pyridopyrimidine[A176792] that acts in the cell cycle machinery. … [L5867] It was originally FDA approved on March 2015 for the treatment of HR-positive, HER2-negative advanced or metastatic breast cancer and its indications were updated in April 2019 to include male
Trolamine
go.drugbank.com/drugs/DB13747ApprovedInvestigationalIt is commonly used as a pH adjuster and surfactant in industrial and cosmetic products such as skin and hair conditioning products. … Trolamine contains small amounts of diethanolamine and ethanolamine and may also act as an antioxidant against the auto-oxidation of animal and vegetable fats [A27174].
Lipoic acid
go.drugbank.com/drugs/DB00166ApprovedInvestigationalNutraceuticalA vitamin-like antioxidant.
Categories: Compounds used in a research, industrial, or household setting, Vitamin B ComplexFentanyl
go.drugbank.com/drugs/DB00813ApprovedIllicitInvestigationalVet approved[A179542] In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths).[L6748] Opioid overdoses kill an average of 11 Canadians daily. … [L6751] Fentanyl was FDA approved in 1968.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613]
Synonyms: N-phenethyl-4-(N-propionylanilino)piperidine, N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamideProducts: Actiq 200 Mikrogramm Lutschtablette, gepresst, mit integriertem Applikator zur Anwendung in der Mundhöhle, Actiq 400 Mikrogramm Lutschtablette, gepresst, mit integriertem Applikator zur Anwendung in der MundhöhleSiponimod
go.drugbank.com/drugs/DB12371ApprovedInvestigational[L5801] MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792] … It was approved by the FDA on March 26, 2019 [L5792] and by Health Canada on February 20, 2020.
Ephedra sinica root
go.drugbank.com/drugs/DB01363ApprovedNutraceuticalThe drug is still sold in Canada in OTC formulations for respiratory conditions associated with bronchial asthma. … The sale of ephedra-containing supplements intended to increase muscle weight or promote weight loss was banned in the United States in 2004 due to the risk for adverse effects and a lack of evidence for
Categories: Complex MixturesSynonyms: Ma huang gen (ephedra sinica)Procaine
go.drugbank.com/drugs/DB00721ApprovedInvestigationalVet approved(From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). Procaine has also been investigated as an oral entry inhibitor in treatment-experienced HIV patients [L1215].
Fluciclovine (18F)
go.drugbank.com/drugs/DB13146ApprovedInvestigationalIt presents excellent diagnostic properties to be used in positron emission tomography (PET) imaging. … [A31385] Fluciclovine was developed by Blue Earth Diagnostics, Ltd. and FDA approved in May 27, 2016.[L1049]