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Displaying results 1951 - 1960 of 5506 in total
  1. Drug

    Calcium polycarbophil

    go.drugbank.com/drugs/DB14684
    Approved

    It is insoluble in water, dilute acids, and dilute alkali. … Based on its chemical structure, it is a synthetic polymer of polyacrylic acid cross-linked with divinyl glycol presenting a calcium atom as a counter-ion.

  2. Drug

    Dordaviprone

    go.drugbank.com/drugs/DB14844
    ApprovedInvestigational

    [L53838] It is used to treat patients with diffuse midline glioma harboring an H3 K27M mutation. … activation of mitochondrial caseinolytic protease P (ClpP), antagonism of the dopamine D2 receptor,[L53833] activation of Activating Transcription Factor 4 (ATF4), and induction of endoplasmic reticulum (ER

    Synonyms: 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo(1,2-A)pyrido(3,4-E)pyrimidin-5(4H)-one, 2,4,6,7,8,9-Hexahydro-4-((2-methylphenyl)methyl)-7-phenylmethyl)imidazo)(1,2-a)pyrido(3,4-e)pyrimidin-5(1H)-one
  3. Drug

    Talimogene laherparepvec

    go.drugbank.com/drugs/DB13896
    ApprovedInvestigational

    It specifically replicates within tumor cells and causes lysis. It was approved by the FDA in 2015 under the market name Imlygic. … In general, talimogene laherparepvec has been modified so that it can infect and multiply inside melanoma cells [L2221].

    Synonyms: T Vec, T-Vec
  4. Drug

    Erdafitinib

    go.drugbank.com/drugs/DB12147
    ApprovedInvestigational

    [L5956, L5959] At the same time, the FDA also approved the therascreen FGFR RGQ RT-PCR Kit (Qiagen) for utilization as a companion diagnostic with erdafitinib for selecting patients for the indicated therapy

  5. Drug

    Normethadone

    go.drugbank.com/drugs/DB11609
    ApprovedIllicit

    It is marketed in Canada by Valeant under the tradename Cophylac.

  6. Drug

    Fenoprofen

    go.drugbank.com/drugs/DB00573
    Approved

    It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.

  7. Drug

    Thiamylal

    go.drugbank.com/drugs/DB01154
    ApprovedVet approved

    (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)

  8. Drug

    Benralizumab

    go.drugbank.com/drugs/DB12023
    ApprovedInvestigational

    It is an afucosylated IgG which gives it high affinity for the FcγRIIIα receptor in natural killer cells, macrophages and neutrophils. … [A31294] It inhibits the binding of IL-5 as well as the hetero-oligomerization of the alpha and beta subunits of the IL-5R, thus blocking signal transduction.

    Products: Fasenra 30mg Solution for Injection in Pre-filled Pen, FASENRA SOLUTION FOR INJECTION 30MG/ML (AUTOINJECTOR PEN)
  9. Drug

    Isoflurophate

    go.drugbank.com/drugs/DB00677
    ApprovedWithdrawn

    (From Martindale, The Extra Pharmacopoeia, 29th ed, p1330) … It is a powerful miotic used mainly in the treatment of glaucoma. Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutically.

  10. Drug

    Difluprednate

    go.drugbank.com/drugs/DB06781
    ApprovedInvestigational

    It is indicated for treatment of endogenous anterior uveiti. … It is a butyrate ester of 6(α), 9(α)-difluoro prednisolone acetate. Difluprednate is abbreviated DFBA, or difluoroprednisolone butyrate acetate.