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L-selectin
go.drugbank.com/bio_entities/BE0010361TargetHumansCalcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28011641, PubMed:28489325). Mediates the adherence of lymphocytes to endothelial cells of high endothelial ven...
Synonyms: Lymph node homing receptorCalcium-activated potassium channel subunit beta-4
go.drugbank.com/bio_entities/BE0004424TargetHumansRegulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium se...
Synonyms: Charybdotoxin receptor subunit beta-4Calcium-activated potassium channel subunit beta-2
go.drugbank.com/bio_entities/BE0003196TargetHumansRegulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers ra...
Synonyms: Charybdotoxin receptor subunit beta-2Codeine
go.drugbank.com/drugs/DB00318ApprovedIllicitInvestigationalThe relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US...
Mixtures: Notuss PE, M-end PECategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCangrelor
go.drugbank.com/drugs/DB06441ApprovedInvestigationalCangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y...
Categories: Purinergic P2 Receptor Antagonists, Purinergic P2Y Receptor AntagonistsE3 ubiquitin-protein ligase XIAP
go.drugbank.com/bio_entities/BE0001156TargetHumansMulti-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis...
Synonyms: Baculoviral IAP repeat-containing protein 4Protein-tyrosine kinase 2-beta
go.drugbank.com/bio_entities/BE0000871TargetHumansNon-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. … Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels.
Synonyms: Calcium-regulated non-receptor proline-rich tyrosine kinaseMedical Cannabis
go.drugbank.com/drugs/DB14009InvestigationalThe use of the plant species _Cannabis sativa_ and _Cannabis indica_, popularly known as marijuana, has gained popularity in recent years for the management of a wide variety of medical conditions as a … In contrast to THC's weak agonist activity, CBD has been shown to act as a negative allosteric modulator of the cannabinoid CB1 receptor, the most abundant G-Protein Coupled Receptor (GPCR) in the body
Categories: Cytochrome P-450 CYP1A2 Inducers, P-glycoprotein inhibitorsTIR domain-containing adapter molecule 1
go.drugbank.com/bio_entities/BE0016552TargetHumansInvolved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:125390...
Synonyms: Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon betaProlgolimab
go.drugbank.com/drugs/DB16740InvestigationalCategories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors