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Displaying results 1971 - 1980 of 10000 in total
  1. Target

    Sestrin-2

    go.drugbank.com/bio_entities/BE0013521
    TargetHumans

    Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26586190, PubMed:26612684, PubMed:3...

    Synonyms: Hypoxia-induced gene
  2. Drug

    Obinepitide

    go.drugbank.com/drugs/DB05045
    Experimental

    In obinepitide, the properties of both of these hormones have been implanted into a single molecule. … Obinepitide is a synthetic analogue of two natural human hormones, PYY and Pancreatic Polypeptide, which normally are released during a meal.

    Synonyms: (34-L-glutamine)pancreatic hormone (human)
  3. Drug

    Lacosamide

    go.drugbank.com/drugs/DB06218
    ApprovedInvestigational

    Lacosamide exhibits a stereoselective mode of interaction with sodium channels. … As a chiral functionalized amino acid, it works by blocking slowly inactivating components of voltage-gated sodium currents.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: (R)-2-acetamido-N-benzyl-3- methoxypropionamide, (R)-LACOSAMIDE 1
  4. Drug

    Panobinostat

    go.drugbank.com/drugs/DB06603
    ApprovedInvestigational

    Panobinostat acts as a non-selective histone deacetylase inhibitor (pan-HDAC inhibitor) and it is the most potent DAC inhibiting agent available on the market.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylamide, 2-PROPENAMIDE, N-HYDROXY-3-(4-(((2-(2-METHYL-1H-INDOL-3-YL)ETHYL)AMINO)METHYL)PHENYL)-, (2E)-
  5. Drug

    Estradiol valerate

    go.drugbank.com/drugs/DB13956
    ApprovedInvestigationalVet approved

    As a pro-drug of estradiol, estradiol acetate therefore has the same downstream effects within the body through binding to the Estrogen Receptor (ER) including ERα and ERβ subtypes, which are located in … Estradiol Valerate (also known as E2V) is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously within the human body.

    Mixtures: DIVICONT TABLETAS 1 MG/5 MG, Velbienne 1 mg/2 mg FilmtablettenCategories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  6. Drug

    Levothyroxine

    go.drugbank.com/drugs/DB00451
    ApprovedInvestigational

    While T<sub>4</sub> is the major product secreted by the thyroid gland, T<sub>3</sub> exerts the majority of the physiological effects of the thyroid hormones; T<sub>4</sub> and T<sub>3</sub> have a relative … potency of ~1:4 (T4:T3).

    Mixtures: L THYROX JOD HEXAL 50/150, L THYROX JOD HEXAL 50/150Categories: P-glycoprotein inducers, Cytochrome P-450 CYP2C8 Inhibitors
  7. Drug

    Aldesleukin

    go.drugbank.com/drugs/DB00041
    ApprovedInvestigational

    Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. … Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene.

    Categories: Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 CYP3A InhibitorsSynonyms: 125-L-Serine-2-133-interleukin 2, 125-L-serine-2-133-interleukin 2 (human reduced)
  8. Drug

    Rose bengal

    go.drugbank.com/drugs/DB11182
    ApprovedInvestigational

    Rose bengal is a pink stain derived as an analogue of fluorescein. Its disodium salt in ophthalmic solutions has been used as a diagnostic agent in suspected damage to conjunctival and corneal cells. … A direct cytotoxic effect of Rose bengal on microorganisms and cancer cells has been observed, questioning its potential antitumor actions via intralesional injections.

    Categories: Heterocyclic Compounds, 3-Ring, Compounds used in a research, industrial, or household setting
  9. Drug

    (S)-camphor

    go.drugbank.com/drugs/DB11345
    Approved

    It has been used as a nasal decongestant and cough suppressant, and has been topically applied due to its antipruritic, analgesic, and counterirritant properties [A33086]. … (S)-camphor, or L(-)-Camphor, is a stereoisomer of [DB01744], a bicyclic monoterpene known to potentiate both heat and cold sensations [A33087].

    Mixtures: U Ice Cold, U Ice ColdSynonyms: l-camphor, (−)-bornan-2-one
  10. Drug

    Naltrexone

    go.drugbank.com/drugs/DB00704
    ApprovedInvestigationalVet approved

    It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. … Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone.

    Categories: Heterocyclic Compounds with 4 or More RingsSynonyms: N-Cyclopropylmethylnoroxymorphone, N-Cyclopropylmethyl-14-hydroxydihydromorphinone