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Remimazolam Action Pathway
smpdb.ca/view/SMP0126145Drug actionLike other benzodiazepines, remimazolam exerts its therapeutic effects by potentiating the effect of gamma-aminobutyric acid (GABA) on GABA(A) receptors, the main inhibitory neurotransmitter receptors … They bind to the interface between alpha (α) and gamma (γ) subunits on the receptor, commonly referred to as the benzodiazepine binding site, and modulate the receptor such that its inhibitory response
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Phenobarbital Action Pathway
smpdb.ca/view/SMP0126831Drug actionFunctioning as a nonselective depressant of the central nervous system, it engages inhibitory gamma-aminobutyric acid subtype receptors, thereby modulating chloride currents across receptor channels and … Phenobarbital is absorbed to varying degrees through oral, rectal, or parenteral routes, with the salts exhibiting quicker absorption compared to the acids.
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Phenobarbital · Calcium · Magnesium cation +3 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Zopiclone Action Pathway
smpdb.ca/view/SMP0126832Drug actionOperating outside the benzodiazepine and barbiturate realms, it interacts with the gamma-aminobutyric acid-benzodiazepine (GABABZ) receptor complex, demonstrating both benzodiazepine-like and some barbiturate-like
Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2GABA
smpdb.ca/view/SMP0127038PhysiologicalGamma-aminobutyric acid (GABA) is an amino acid that serves as the primary inhibitory neurotransmitter in the brain and a major inhibitory neurotransmitter in the spinal cord. … After synthesis, it is loaded into synaptic vesicles by the vesicular inhibitory amino acid transporter. SNARE complexes help dock the vesicles into the plasma membrane of the cell.
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Propofol Action Pathway
smpdb.ca/view/SMP0125089Drug actionPropofol is sedative-hypnotic agent injected intravenously to induce and maintain general anaesthesia causing unconsciousness in order to preform surgery. The injection of Propofol produces hypnosis rapidly within 40 seconds from the sta...
Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid receptor subunit alpha-1Stiripentol GABA(A) Antiepileptic Action Pathway
smpdb.ca/view/SMP0126168Drug actionPossible mechanisms of action include direct effects mediated through the gamma-aminobutyric acid GABAA receptor and indirect effects involving inhibition of cytochrome P450 activity.
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +4 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Ganaxolone Action Pathway
smpdb.ca/view/SMP0126153Drug actionGanaxolone belongs to a novel class of neuroactive steroids sometimes referred to as "epalons", which are potent and specific positive allosteric modulators of γ-aminobutyric acid type A (GABAA) receptors
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +3 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Etizolam Action Pathway
smpdb.ca/view/SMP0125057Drug actionEtizolam is a thienodiazepine which is chemically related to benzodiazepine (BDZ) drug class; it differs from BDZs in having a benzene ring replaced with a thiophene ring. It is an agonist at GABA-A receptors and possesses amnesic, anxio...
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Temazepam Action Pathway
smpdb.ca/view/SMP0125058Drug actionTemazepam is a short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and insomnia. Temazepam allosterically binds on the benzodiazepine receptors in the post-synaptic GABA-A ligand-gated chloride channel in ...
Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Clotiazepam Action Pathway
smpdb.ca/view/SMP0126124Drug actionClotiazepam is a thienodiazepine used to manage anxiety disorders and insomnia. Clotiazepam (marketed under brand name Clozan, Distensan, Trecalmo, Rize, Rizen and Veratran) is a thienodiazepine drug which is a benzodiazepine analog. Clo...
Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2