Search

Displaying results 11 - 15 of 15 in total
  1. Target

    Endonuclease 8-like 1

    go.drugbank.com/bio_entities/BE0003175
    TargetHumans

    Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases.

    Synonyms: DNA-(apurinic or apyrimidinic site) lyase Neil1Function: class I DNA-(apurinic or apyrimidinic site) endonuclease activity
  2. Target

    Endonuclease 8-like 2

    go.drugbank.com/bio_entities/BE0005817
    TargetHumans

    Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. … Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.

    Synonyms: DNA-(apurinic or apyrimidinic site) lyase Neil2Function: class I DNA-(apurinic or apyrimidinic site) endonuclease activity
  3. Target

    DNA repair nuclease/redox regulator APEX1

    go.drugbank.com/bio_entities/BE0002414
    TargetHumans

    Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression (PubMed:11809897, PubMed:14633989, PubMed:8621488). … Has 3'-5' exodeoxyribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER (PubMed:11832948, PubMed:1719477).

    Synonyms: DNA-(apurinic or apyrimidinic site) endonuclease
  4. Target

    Interferon lambda receptor 1

    go.drugbank.com/bio_entities/BE0016547
    TargetHumans

    The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN...

    Synonyms: Likely interleukin or cytokine receptor 2
  5. Target

    3-hydroxyacyl-CoA dehydrogenase type-2

    go.drugbank.com/bio_entities/BE0000317
    TargetEnzymeHumans

    Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism (PubMed:10600649, PubMed:12917011, PubMed:18996107, PubMed:19706438, PubMed:20077426, PubMed:25925575, PubMed:26950678, PubM...

    Synonyms: 3alpha(or 20beta)-hydroxysteroid dehydrogenase