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Displaying results 11 - 20 of 605 in total
  1. Target

    Coagulation factor XIII A chain

    go.drugbank.com/bio_entities/BE0000004
    TargetEnzymeHumans

    Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot

    Polypeptides: Coagulation factor XIII A chainSynonyms: Coagulation factor XIIIa
  2. Target

    Coagulation factor XIII B chain

    go.drugbank.com/bio_entities/BE0009075
    TargetHumans

    The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin

    Polypeptides: Coagulation factor XIII B chainSynonyms: Fibrin-stabilizing factor B subunit
  3. Target

    Human Cyclooxygenases

    go.drugbank.com/bio_entities/BE0010085
    TargetHumans

    Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols (PubMed:11034610, PubMed:11192938, PubMed:9048568, PubMed:9261177). … Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to PGH1 and PGH3, the precursors of 1- and 3-series

  4. Target

    Human Carboxylesterases

    go.drugbank.com/bio_entities/BE0010086
    EnzymeTargetHumans

    Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105). … Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443).

  5. Target

    Human Isocitrate Dehydrogenases

    go.drugbank.com/bio_entities/BE0010093
    TargetHumans

    The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity … The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity

  6. Target

    Multiple coagulation factor deficiency protein 2

    go.drugbank.com/bio_entities/BE0002120
    TargetHumans

    Plays a role in the secretion of coagulation factors

    Polypeptides: Multiple coagulation factor deficiency protein 2
  7. Target

    Platelet glycoprotein IX

    go.drugbank.com/bio_entities/BE0000866
    TargetHumans

    GP-IX may provide for membrane insertion and orientation of GP-Ib … The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels.

    Polypeptides: Platelet glycoprotein IXSynonyms: GP-IX
  8. Target

    Quinohemoprotein alcohol dehydrogenase

    go.drugbank.com/bio_entities/BE0001870
    TargetComamonas testosteroni

    Catalyzes the dye-linked oxidation of primary alcohols to the corresponding aldehydes and the (subsequent) oxidation of the aldehydes to carboxylic acids. Methanol is not a substrate.

    Polypeptides: Quinohemoprotein alcohol dehydrogenaseSynonyms: Alcohol dehydrogenase (azurin), PQQ-containing alcohol dehydrogenase
  9. Target

    Human vesicular glutamate transporters

    go.drugbank.com/bio_entities/BE0009848
    TransporterTargetHumans

  10. Target

    Human telomerase RNA component

    go.drugbank.com/bio_entities/BE0011002
    TargetHumans