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Voriconazole Action Pathway
smpdb.ca/view/SMP0125441Drug actionIt is taken orally and used to treat esophageal candidiasis, cadidemia, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. … It has an increased affinity to 14-alpha sterol demethylase, and therefore makes it useful against fluconazole-resistant fungal infections.
Luliconazole Action Pathway
smpdb.ca/view/SMP0125821Drug actionWithout ergosterol, the fungus cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells. This leads to cell lysis which causes it to collapse and die. … It was approved by the FDA (USA) in November 2013 and is marketed under the brand name Luzu. Luliconazole is also approved in Japan.
Posaconazole Action Pathway
smpdb.ca/view/SMP0125831Drug actionWithout ergosterol, the fungus cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells. This leads to cell lysis which causes it to collapse and die. … For prophylaxis of invasive Aspergillus and Candida infections in patients, 13 years of age and older, who are at high risk of developing these infections due to being severely immunocompromised as a result
Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
smpdb.ca/view/SMP0000373Disease, aldosterone and cortisol. … Symptoms include salt-wasting crises in infancy due to the lack of aldosterone, like spitting, poor weight gain, vomiting, severe dehydration, and circulatory collapse.
Sertaconazole Action Pathway
smpdb.ca/view/SMP0125419Drug actionSertaconazole might also inhibit endogenous respiration, interact with membrane phospholipids, inhibit transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or … Without ergosterol, the fungus cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells. This leads to cell lysis which causes it to collapse and die.
Isoconazole Action Pathway
smpdb.ca/view/SMP0125819Drug actionWithout ergosterol, the fungus cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells. This leads to cell lysis which causes it to collapse and die. … Isoconazole is an imidazole antifungal used for superficial skin and vaginal infections.
Ketoconazole Anti-fungal Action Pathway
smpdb.ca/view/SMP0125162Drug actionKetoconazole also causes an accumulation of 14α-methyl-3,6-diol which is toxic to the cell and will also kill the fungal cell and the cell membrane. … The lack of ergosterol increases cell permeability which allows intracellular components to leak out and eventually the fungal cell collapses and dies.
Econazole Action Pathway
smpdb.ca/view/SMP0125404Drug actionThis enzyme catalyzes the reaction of lanosterol with 3 oxygen and 3 NADPH to become 4,4-Dimethylcholesta-8,14,24-trienol with byproducts of formic acid, 4 hydrogen ions, 4 water, and 3 NADP+. … Econazole is a topical antifungal used to treat skin fungal infections such as athlete's foot, jock itch, and ringworm. It is a foam known as the brand name Ecoza, applied to the infected area.
Bifonazole Action Pathway
smpdb.ca/view/SMP0125418Drug actionWithout ergosterol, the fungus cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells. This leads to cell lysis which causes it to collapse and die. … Bifonazole is an azole anti-fungal drug used to treat fungal skin infections, such as dermatomycosis and athlete's foot. It comes as a cream which is spread on the infected skin.
Butoconazole Action Pathway
smpdb.ca/view/SMP0125812Drug actionWithout ergosterol, the fungus cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells. This leads to cell lysis which causes it to collapse and die. … Butoconazole is an imidazole antifungal used to treat vulvovaginal candidiasis.