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Pentobarbital Action Pathway
smpdb.ca/view/SMP0126165Drug actionA short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. … All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa).
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Pentobarbital · Calcium · Magnesium cation +3 moreEnzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1AMethsuximide Action Pathway
smpdb.ca/view/SMP0126331Drug actionVoltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone … The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil.
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +3 moreEnzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent T-type calcium channel subunit alpha-1GDipyridamole (Antiplatelet) Action Pathway
smpdb.ca/view/SMP0000264Drug actionDipyridamole (also known as Persantine) can bind and inhibit cAMP-specific 3',5'-cyclic phosphodiesterase 4D at platelet cell, which prevent the release of arachidonic acid form membrane phospholipids … Dipyridamole can also induce adenylate cyclase activity by releasing prostacyclin, which lead to inhibition of platelet aggregation and increased intraplatelet concentration of cAMP.
Cilazapril Metabolism Pathway
smpdb.ca/view/SMP0000592Drug metabolismConsequently, ACE inhibitors decrease angiotensin II concentrations and increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure. … This drug can also be used in the treatment of congestive heart failure and type II diabetes.
Quinapril Metabolism Pathway
smpdb.ca/view/SMP0000596Drug metabolismConsequently, ACE inhibitors decrease angiotensin II concentrations and increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure. … This drug can also be used in the treatment of congestive heart failure and type II diabetes.
Trandolapril Metabolism Pathway
smpdb.ca/view/SMP0000599Drug metabolismConsequently, ACE inhibitors decrease angiotensin II concentrations and increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure. … This drug can also be used in the treatment of congestive heart failure and type II diabetes.
Gefitinib Action Pathway (New)
smpdb.ca/view/SMP0122919Drug actionMAPK is activated through the epidermal growth factor receptor on the cell membrane and goes on to phosphorylate and regulate the activities of several transcription factors affecting cellular growth and … Gefitinib is an epidermal growth factor receptor tyrosine kinase inhibitor used to treat tumors and certain cancers.
Degradation of Superoxides
smpdb.ca/view/SMP0000468MetabolicExamples are superoxide, oxygen ions and peroxides and can be of either organic or inorganic origin. … Catalase attacks the hydrogen peroxide produced by SODs, and converts it into oxygen and water.
Fosinopril Metabolism Pathway
smpdb.ca/view/SMP0000594Drug metabolismConsequently, ACE inhibitors decrease angiotensin II concentrations and increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure. … This drug can also be used in the treatment of congestive heart failure and type II diabetes.
Moexipril Metabolism Pathway
smpdb.ca/view/SMP0000595Drug metabolismConsequently, ACE inhibitors decrease angiotensin II concentrations and increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure. … This drug can also be used in the treatment of congestive heart failure and type II diabetes.