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Splicing factor 3B subunit 3
go.drugbank.com/bio_entities/BE0009020TargetHumansSequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). … The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA
Polypeptides: Splicing factor 3B subunit 3Synonyms: Pre-mRNA-splicing factor SF3b 130 kDa subunitVascular endothelial growth factor C
go.drugbank.com/bio_entities/BE0010101TargetHumansGrowth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. … Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors
Polypeptides: Vascular endothelial growth factor CSynonyms: Vascular endothelial growth factor-related proteinVascular endothelial growth factor D
go.drugbank.com/bio_entities/BE0010102TargetHumansGrowth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. … Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors
Polypeptides: Vascular endothelial growth factor DSynonyms: c-Fos-induced growth factorElongation factor 1-alpha 2
go.drugbank.com/bio_entities/BE0010196TargetHumansBase pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). … Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis.
Polypeptides: Elongation factor 1-alpha 2Synonyms: Eukaryotic elongation factor 1 A-2Vascular endothelial growth factor receptor
go.drugbank.com/bio_entities/BE0010227TargetHumansModulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. … Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated
Polypeptides: Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2Synonyms: Vascular permeability factor receptorInsulin-like growth factor 2
go.drugbank.com/bio_entities/BE0010370TargetHumansInhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity) … Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity).
Polypeptides: Insulin-like growth factor 2Synonyms: Insulin-like growth factor II, T3M-11-derived growth factorCytokine receptor-like factor 2
go.drugbank.com/bio_entities/BE0010586TargetHumansForms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity).
Polypeptides: Cytokine receptor-like factor 2Interleukin enhancer-binding factor 3
go.drugbank.com/bio_entities/BE0014107TargetHumansAs a consequence, participates in a wide range of transcriptional and post-transcriptional processes. … Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398).
Polypeptides: Interleukin enhancer-binding factor 3Synonyms: Nuclear factor associated with dsRNA, Nuclear factor of activated T-cells 90 kDaMultifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
go.drugbank.com/bio_entities/BE0002195TargetEnzymeHumansCatalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:25419660). … Essential for normal biosynthesis and secretion of type IV collagens (Probable) (PubMed:18834968). Essential for normal formation of basement membranes (By similarity)
Polypeptides: Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3Disintegrin and metalloproteinase domain-containing protein 9
go.drugbank.com/bio_entities/BE0003412TargetHumansMetalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. … May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 9