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Tenapanor
go.drugbank.com/drugs/DB11761ApprovedInvestigationalTenapanor is a novel, small molecule medication approved in September 2019 for the treatment of constipation-predominant irritable bowel-syndrome (IBS-C). … [A185492] As an inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3) transporter, it is the first and currently only medication within its class[A185489,A185492,A185495] and therefore exists as
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesFenfluramine
go.drugbank.com/drugs/DB00574ApprovedIllicitInvestigationalWithdrawnIt is currently sold under the name FINTEPLA® by Zogenix INC.[L14522] … Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures.
Synonyms: 1-(m-trifluoromethyl-phenyl)-2-ethylaminopropaneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesPegvaliase
go.drugbank.com/drugs/DB12839ApprovedInvestigationalPhenylketonuria is a rare autosomal recessive disorder that is characterized by deficiency of the enzyme phenylalanine hydroxylase (PAH) [A33284] and affects about 1 in 10,000 to 15,000 people in the United … Pegvaliase-pqpz, or PEGylated pegvaliase, is used as a novel enzyme substitution therapy and is marketed as Palynziq for subcutaneous injection.
Omaveloxolone
go.drugbank.com/drugs/DB12513ApprovedInvestigationalIn patients with Friedreich's ataxia, a genetic disease involving mitochondrial dysfunction, the Nrf2 pathway is impaired, and Nrf2 activity is lower. … Omaveloxolone (RTA-408) is a semisynthetic oleanane triterpenoid with antioxidant and anti-inflammatory properties.
Synonyms: Propanamide, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-Categories: Cytochrome P-450 CYP2C8 Inducers, Cytochrome P-450 SubstratesAcoramidis
go.drugbank.com/drugs/DB17999ApprovedInvestigational[A264768] Although they share a mechanism of action, acoramidis is more selective for TTR and is a more potent stabilizer when compared to tafamidis. … Acoramidis is a small molecule stabilizer of transthyretin (TTR) for use in patients with TTR amyloidosis.
Synonyms: 3-(3-(3,5-dimethyl-1h-pyrazol-4-yl)propoxy)-4-fluorobenzoic acidCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2C9 InhibitorsAlclofenac
go.drugbank.com/drugs/DB13167ApprovedWithdrawnAlclofenac is a non-steroidal anti-inflammatory drug. It was withdrawn from the market in the United Kingdom in 1979.
Synonyms: 3-Chloro-4-(2-propenyloxy)benzeneacetic acid, (4-Allyloxy-3-chlorphenyl)essigsäureCategories: Non COX-2 selective NSAIDSCladribine
go.drugbank.com/drugs/DB00242ApprovedInvestigationalCladribine is a purine analogue or a chlorinated derivative of adenine [A263733] that causes apoptosis of B and T lymphocytes. … [A350] Cladribine was first approved in the United States in 1993 [A263713] initially as a treatment for a number of hematological malignancies; currently, it is approved for the treatment of hairy cell
Synonyms: (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-6-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)purineCategories: 2-Chloroadenosine, P-glycoprotein substratesBotulinum toxin type A
go.drugbank.com/drugs/DB00083ApprovedInvestigational[A231824] With a wide variety of applications and favourable safety profile, Botulinum toxin A injection is a minimally invasive and promising treatment for cosmetic imperfections, muscle spasms, and other … [A231819,L32569] A popular use for Botox is the treatment of facial wrinkles and lines, however, there are many uses for the botulinum toxin A in the treatment of dystonia, incontinence, migraine, blepharospasm
Synonyms: BTX A, BTX-ACategories: Botulinum Toxins, Type ADocetaxel
go.drugbank.com/drugs/DB01248ApprovedInvestigationalDocetaxel is a complex diterpenoid molecule and a semisynthetic analogue of [paclitaxel]. … Docetaxel is a clinically well established anti-mitotic chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and non-small cell lung cancer.
Synonyms: N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol, N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxelCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexAxicabtagene ciloleucel
go.drugbank.com/drugs/DB13915ApprovedInvestigationalIt is marketed under the brand name Yescarta and is used to treat large B-cell lymphomas and follicular lymphoma in adults. … Axicabtagene ciloleucel is an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy.
Synonyms: Autologous T cells transduced with retroviral vector encoding an anti-CD-19 CD28/CD3-zeta chimeric antigen receptorCategories: Antigens, Differentiation, B-Lymphocyte, Genetically-modified Autologous T Cells