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Displaying results 2001 - 2010 of 2254 in total
  1. Indication

    XLH

    go.drugbank.com/conditions/DBCOND0125908
    Drugs: Burosumab
    Synonyms: Calcitriol receptor defect
  2. Drug

    Pravastatin

    go.drugbank.com/drugs/DB00175
    ApprovedInvestigational

    Pravastatin is the 6-alpha-hydroxy acid form of mevastatin. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug....

  3. Target

    P2X purinoceptor 3

    go.drugbank.com/bio_entities/BE0009818
    TargetHumans

    Extracellular ATP-activated non-selective cation channel (PubMed:10440098, PubMed:27626375, PubMed:29674445, PubMed:31232692). Plays particularly important role in sensory neurons where its activation is critical for gustatory, nocicepti...

    Synonyms: ATP receptor, Purinergic receptor
  4. Target

    P2X purinoceptor 2

    go.drugbank.com/bio_entities/BE0009820
    TargetHumans

    ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:10570044, PubMed:31636190). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic r...

    Synonyms: ATP receptor, Purinergic receptor
  5. Target

    P2 Purinoceptors

    go.drugbank.com/bio_entities/BE0009827
    Target

    Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (PubMed:35165166). … In lymphoid follicles, confines B cells and follicular helper T cells in germinal centers (GCs) in response to GGG local gradients established by GGT5 (via GGG catabolism) and ABCC1 (via extracellular

    Polypeptides: Lysophosphatidic acid receptor 4, Lysophosphatidic acid receptor 6Synonyms: LPA receptor 4, LPA receptor 6
  6. Drug

    Eflapegrastim

    go.drugbank.com/drugs/DB15001
    ApprovedInvestigational

    [L43135] Eflapegrastim is a form of recombinant human G-CSF comprising a human G-CSF analog coupled to the Fc fragment of human IgG4 via a polyethylene glycol linker.

  7. Drug

    Capmatinib

    go.drugbank.com/drugs/DB11791
    ApprovedInvestigational

    [A199122] Aberrant c-Met activation - via mutations, amplification, and/or overexpression - is known to occur in many types of cancer, and leads to overactivation of multiple downstream signaling pathways … Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades

  8. Target

    P2X purinoceptor 4

    go.drugbank.com/bio_entities/BE0005793
    TargetHumans

    Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (PubMed:35165166). … Upon activation, drives microglia motility via the PI3K/Akt pathway (By similarity). Could also function as an ATP-gated cation channel of lysosomal membranes (By similarity)

    Synonyms: ATP receptor, Purinergic receptor
  9. Target

    P2Y purinoceptor 1

    go.drugbank.com/bio_entities/BE0009816
    TargetHumans

    Receptor for extracellular adenine nucleotides such as ADP (PubMed:25822790, PubMed:9038354, PubMed:9442040). … In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040)

    Synonyms: ADP receptor, Purinergic receptorFunction: A1 adenosine receptor binding
  10. Drug

    Methylphenidate

    go.drugbank.com/drugs/DB00422
    ApprovedInvestigational

    [L6037] CADDRA recommends the use of methylphenidate due to long term studies, of over twenty years in duration, which show methylphenidate is safe and effective. … Water then permeates through the membrane into the tablet core where the osmotically active polymer excipients expand, allowing methylphenidate to release slowly through the orifice over a period of 6-