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Crofelemer
go.drugbank.com/drugs/DB04941ApprovedInvestigationalCrofelemer, previously known as the investigational drug SP-303, is a novel proanthocyanidin purified from the bark latex of the Amazonian Croton tree <i>Croton lechleri</i>. … It is marketed under the brand name Fulyzaq and indicated for the symptomatic treatment of non-infectious diarrhea in adult patients with HIV/AIDS who are taking antiretroviral therapy.
Categories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-RingFerric oxide
go.drugbank.com/drugs/DB11576ApprovedInvestigationalIt is one of the three main oxides of iron, the other two being iron(II) oxide (FeO) the rarer form, and iron(II,III) oxide (Fe3O4) which naturally as magnetite. … Iron(III) oxide or ferric oxide is the inorganic compound with the formula Fe2O3.
Mixtures: Cellzyme ON-TOX, Cellzyme ON-TOXCategories: Compounds used in a research, industrial, or household settingSuccimer
go.drugbank.com/drugs/DB00566ApprovedInvestigationalA mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.
Categories: Compounds used in a research, industrial, or household settingSynonyms: DMS-ABoceprevir
go.drugbank.com/drugs/DB08873ApprovedWithdrawnwith [DB00811], [DB00008], and [DB00022] as first line therapy for Hepatitis C [A19593]. … Approved in May 2011 by the FDA, Victrelis is indicated for the treatment of HCV genotype 1 in combination with [DB00811], [DB00008], and [DB00022] [FDA Label].
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: VICTRELIS ® CAPSULAS 200 MG (MOLECULA PROTEGIDA)Laromustine
go.drugbank.com/drugs/DB05817InvestigationalVNP40101M is a novel alkylating agent that has been used in trials studying the treatment of Leukemia, Lymphoma, Lung Cancer, Small Intestine Cancer, and Myelodysplastic Syndromes, among others.
Categories: Cytochrome P-450 CYP2B6 Inhibitors, Cytochrome P-450 SubstratesSofosbuvir
go.drugbank.com/drugs/DB08934ApprovedInvestigationalIn a joint recommendation published in 2016, the American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) recommend Sofosbuvir as first line therapy … Both Canadian and American guidelines list Epclusa as a first line recommendation for all genotypes of HCV [L852, A19626].
Mixtures: HARVONI®, EPCLUSA®Categories: P-glycoprotein substrates, Treatments for Hepatitis CLoratadine
go.drugbank.com/drugs/DB00455ApprovedInvestigationalLoratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. … [A176435] A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.
Mixtures: THERAFLU N 12, SENSIBIT-RINCategories: P-glycoprotein inhibitors, P-glycoprotein substratesArachidonic Acid Metabolism
smpdb.ca/view/SMP0000075MetabolicIn resting cells arachidonic acid is present in the phospholipids (especially phosphatidylethanolamine and phosphatidylcholine) of membranes of the body’s cells, and is particularly abundant in the brain … The enzyme 5-lipoxygenase leads to 5-HPETE, which in turn is used to produce the leukotrienes, hydroxyeicosatetraenoic acids (HETEs) and lipoxins.
Enzymes: Prostaglandin E synthaseAcetylsalicylic Acid Action Pathway
smpdb.ca/view/SMP0000083Drug actionIn addition to its anti-inflammatory properties, aspirin also acts as an analgesic, antipyretic and antithrombotic agent. … Platelets contain COX-1, a key enzyme in the production thromboxane A2 (TXA2), which is a potent inducer of platelet aggregation.
Drugs: Glutamic acid · Glutathione · Dinoprostone · Acetylsalicylic acid · Calcium · Magnesium cation +5 moreEnzymes: Prostaglandin E synthaseKetoprofen Action Pathway
smpdb.ca/view/SMP0000085Drug actionProstaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway.
Enzymes: Prostaglandin E synthase