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Furosemide
go.drugbank.com/drugs/DB00695ApprovedInvestigationalVet approved[A182495] The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. … Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative.
Mixtures: SPIRO COMP FORTE RAT100/20, SPIRO COMP FORTE RAT100/20Synonyms: 4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid, 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acidSpesolimab
go.drugbank.com/drugs/DB15626ApprovedInvestigationalIt is a humanized monoclonal immunoglobulin G1 antibody that was produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology. … in December 2022 for the treatment of flares in adult patients with generalized pustular psoriasis.
Perampanel
go.drugbank.com/drugs/DB08883ApprovedInvestigationalPerampanel is a noncompetitive AMPA glutamate receptor antagonist. … The FDA label includes an important black-boxed warning of serious or life-threatening behavioral and psychiatric reactions in patients taking Fycompa™.
Atomoxetine
go.drugbank.com/drugs/DB00289ApprovedInvestigational[A18262] This is beneficial in the treatment of ADHD as DA activation in the subcortical NA and striatum is associated with many stimulant-associated side effects and an increase in abuse potential, which … [A178090] Atomoxetine has been shown to specifically increase NA and DA within the prefrontal cortex, but not in the nucleus accumbens (NA) or striatum.
Products: ATOMOXE 1A PHARMA 10MG, ATOMOXE 1A PHARMA 18MGTolrestat
go.drugbank.com/drugs/DB02383ApprovedWithdrawnWhile it was approved for marketed in several countries, it failed a Phase III trial in the U.S. due to toxicity and never received FDA approval. … Tolrestat (INN) (AY-27773) is an aldose reductase inhibitor which was approved for the control of certain diabetic complications.
Categories: Drugs Used in DiabetesPhloxine B
go.drugbank.com/drugs/DB13911ApprovedWithdrawnPhloxine B (commonly known simply as phloxine, also known as D&C RED NO. 28) is a color additive which is used both as an inactive ingredient to provide color to products, or as a colorant in dental disclosing
Categories: Compounds used in a research, industrial, or household settingGalactose
go.drugbank.com/drugs/DB11735ApprovedInvestigationalWithdrawnAs a naturally occurring sugar, it may be found in a number dairy products. Even then, however, it is not generally used as a sweetener considering it is only about 30% as sweet as sucrose. … Regardless, although it is predominantly used as a pathway to generate glucose fuel for the human body, galactose is involved as an ingredient in some commonly used vaccines and non-prescription products
Calnexin
go.drugbank.com/bio_entities/BE0001011TargetHumansAssociated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation.
Synonyms: Major histocompatibility complex class I antigen-binding protein p88NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
go.drugbank.com/bio_entities/BE0000081TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Synonyms: Complex I-42kDUrea C-13
go.drugbank.com/drugs/DB09510ApprovedInvestigationalBoth forms can be used within the Urea Breath Test, however some may prefer 13C as it is non-radioactive compared to 14C, which may be preferable in pregnant women and children. … Urea 13C is a urea molecule radiolabelled with the non-radioactive element carbon-13.