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Didanosine
go.drugbank.com/drugs/DB00900ApprovedInvestigationalA dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. … Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative
Categories: Heterocyclic Compounds, 2-RingSynonyms: 9-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one, 9-((2S,5R)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-olOndansetron
go.drugbank.com/drugs/DB00904ApprovedInvestigationalWithdrawnA competitive serotonin type 3 receptor antagonist. … Commonly formulated as oral tablets, orally disintegrating tablets (ODT), and injections, and available as generic products as well, ondansetron continues to see contemporary innovations in its formulation
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: EURODAN, BRYTEROL® TABLETAS X 8 MGTinidazole
go.drugbank.com/drugs/DB00911ApprovedInvestigationalA nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections.
Mixtures: GYNOMAX L VAJINAL OVUL, 7 ADET, GYNOMAX 100 MG/150 MG VAJINAL OVUL, 7 ADETCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingCyclobenzaprine
go.drugbank.com/drugs/DB00924ApprovedInvestigational[A184982] It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond. … Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961[A185039] and has been available for human use since 1977.
Mixtures: DOBRIX ®, Therabenzaprine-90-5Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesPhenoxybenzamine
go.drugbank.com/drugs/DB00925ApprovedInvestigationalIt has been used to treat hypertension and as a peripheral vasodilator.
Categories: Peripheral alpha-1 blockers, Adrenergic alpha-1 Receptor AntagonistsCycrimine
go.drugbank.com/drugs/DB00942ApprovedCycrimine is a drug used to reduce levels of acetylcholine to return a balance with dopamine in the treatment and management of Parkinson's disease.
Categories: Heterocyclic Compounds, 1-RingSynonyms: alpha-cyclopentyl-alpha-phenyl-1-piperidinepropanolZalcitabine
go.drugbank.com/drugs/DB00943ApprovedWithdrawnA dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. … The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one, 2',3'-DideoxycytidineDemecarium
go.drugbank.com/drugs/DB00944ApprovedDemecarium is an indirect-acting parasympathomimetic agent that is used to treat glaucoma. It is a cholinesterase inhibitor or an anticholinesterase. … The outflow of the aqueous humor is facilitated, which leads to a reduction in intraocular pressure.
Fexofenadine
go.drugbank.com/drugs/DB00950ApprovedInvestigational[L4269] It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier[L10779] - this is in contrast to previous first-generation … [A1452] Fexofenadine is the major active metabolite of [terfenadine][A1495] and is administered as a racemic mixture in which both enantiomers display approximately equivalent antihistamine activity.
Mixtures: ALERMED® D, FEXU D® SUSPENSIONCategories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingNaratriptan
go.drugbank.com/drugs/DB00952ApprovedNaratriptan is a triptan drug that is selective for the 5-hydroxytryptamine1 receptor subtype. It is typically used for the treatment of migraine headaches.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: N-methyl-2-(3-(1-methylpiperiden-4-yl)indole-5-yl)ethanesulfonamide, N-methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]-ethanesulfonamide