Phenoxybenzamine is an alpha adrenergic antagonist used to treat pheochromocytoma and episodes of hypertension and sweating. An alpha-adrenergic antagonist with long duration of action.
- Mechanism
- Curator reviewed
Phenoxybenzamine produces its therapeutic actions by blocking alpha receptors, leading to a muscle relaxation and a widening of the blood vessels. This widening of the blood vessels results in a lowering of blood pressure.
- Primary indication
- For the treatment of phaeochromocytoma (malignant), benign prostatic hypertrophy and malignant essential hypertension.Curator reviewed · 3 structured indications
- Formula / weight
- C18H22ClNO · 303.826 g/mol (avg)
- First approval
- United States, 1953
- Also known as
- Fenossibenzamina
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
QZVCTJOXCFMACW-UHFFFAOYSA-NSMILESCC(COC1=CC=CC=C1)N(CCCl)CC1=CC=CC=C1Targets
Transporters
What you can answer from here — as of September 23, 2026
10Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
3TransportersSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Phenoxybenzamine, and which of those have an active Phase 3 trial?
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