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Tezepelumab
go.drugbank.com/drugs/DB15090ApprovedInvestigationalAsthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low endotypes characterized by reduced airflow, chronic inflammation, and airway remodelling. Thymic stromal lymphopoietin (TSLP), an innate...
C-type lectin domain family 14 member A
go.drugbank.com/bio_entities/BE0005467TargetHumansSynonyms: Epidermal growth factor receptor 5Vitamin B12 transporter BtuB
go.drugbank.com/bio_entities/BE0001470TargetTransporterEscherichia coli (strain K12)Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space (PubMed:4579869). It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.
Synonyms: Cobalamin receptorNeuropilin-1
go.drugbank.com/bio_entities/BE0002129TargetHumansCell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system.
Synonyms: Vascular endothelial cell growth factor 165 receptorT-cell surface glycoprotein CD3 zeta chain
go.drugbank.com/bio_entities/BE0003458TargetHumansWhen antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z.
Synonyms: T-cell receptor T3 zeta chainNeuropilin-2
go.drugbank.com/bio_entities/BE0010030TargetHumansHigh affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF
Synonyms: Vascular endothelial cell growth factor 165 receptor 2Abacavir
go.drugbank.com/drugs/DB01048ApprovedInvestigationalAbacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclop...
Mixtures: Triumeq PDLigelizumab
go.drugbank.com/drugs/DB11856InvestigationalInitial trials of ligelizumab suggest a greater efficacy over its predecessor for the treatment of CSU.[A242367]