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Methaqualone
go.drugbank.com/drugs/DB04833ApprovedIllicitWithdrawnIt has also been used illegally as a recreational drug, commonly known as Quaaludes, Sopors, Ludes or Mandrax (particularly in the 1970s in North America) depending on the manufacturer. … Methaqualone is a sedative-hypnotic drug that is similar in effect to barbiturates, a general central nervous system depressant.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingOmidenepag isopropyl
go.drugbank.com/drugs/DB15071Approved[L43503] Omidenepag isopropyl is quickly metabolized to its active metabolite, omidenepag, a molecule with high selectivity and agonistic activity towards the prostaglandin E2 (EP2) receptor. … Omidenepag isopropyl is a topical ocular hypotensive agent used to reduce intraocular pressure (IOP) in patients with glaucoma and ocular hypertension.
Synonyms: isopropyl N-(6-(((4-(1H-pyrazol-1-yl)benzyl)(3-pyridinylsulfonyl)amino)methyl)-2-pyridinyl)glycinateCategories: Heterocyclic Compounds, 1-Ring, Receptors, Prostaglandin E, EP2 Subtype, agonistsMethsuximide
go.drugbank.com/drugs/DB05246ApprovedMesuximide (or methsuximide) is an anticonvulsant medication. It is sold by Pfizer under the name Petinutin.
Synonyms: N,2-Dimethyl-2-phenylsuccinimide, 1,3-Dimethyl-3-phenylsuccinimideCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingEthosuximide
go.drugbank.com/drugs/DB00593ApprovedInvestigationalAn anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.
Synonyms: 2-ethyl-2-methylsuccinimide, (±)-2-ethyl-2-methylsuccinimideCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingTroglitazone
go.drugbank.com/drugs/DB00197ApprovedWithdrawnTroglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by pioglitazone and rosiglitazone.
Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 SubstratesZonisamide
go.drugbank.com/drugs/DB00909ApprovedInvestigational[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors … Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.
Synonyms: Benzo[d]isoxazol-3-yl-methanesulfonamide, 1,2-Benzisoxazole-3-methanesulfonamideCategories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesAbiraterone
go.drugbank.com/drugs/DB05812ApprovedInvestigationalAbiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis
Synonyms: (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol, 17-(3-Pyridyl)androsta-5,16-dien-3beta-olCategories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesMetamizole
go.drugbank.com/drugs/DB04817ApprovedInvestigationalWithdrawnMetamizole (dipyrone) is a pyrazolone derivative that belongs to the group of nonacid nonopioids. It is considered a potent analgesic and antipyretic with favourable gastrointestinal tolerability.
Mixtures: ANTIALGINA®, CAFETRIN ®Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 CYP3A InducersAminophenazone
go.drugbank.com/drugs/DB01424ApprovedWithdrawnIn biomedical applications, radiolabelled (13C-labeled) aminophenazone has been used in breath tests to measure the cytochrome P-450 metabolic activity in liver function tests. … Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties that carries a risk of agranulocytosis.
Categories: Non COX-2 selective NSAIDS, Cytochrome P-450 SubstratesSynonyms: 4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, 1-Phenyl-2,3-dimethyl-4-(dimethylamino)-5-pyrazoloneNimesulide
go.drugbank.com/drugs/DB04743ApprovedWithdrawnNimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. … Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in many countries.
Mixtures: NIMOKAIN %1 + %5 JEL, 50 G, SULIDIN PLUS %1 + %5 LIKIT JEL, 30 GCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates