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Alpelisib
go.drugbank.com/drugs/DB12015ApprovedInvestigationalAlpelisib was designed to target this enzyme that appears to be mutated at a rate of nearly 30% in human cancers, leading to hyperactivation. … To initiate alpelisib therapy, it is required that the presence of a PIK3CA mutation in the tissue and/or liquid biopsy sample collection should be confirmed via FDA-approved diagnostic tests.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: PİMREVA 200 MG FİLM KAPLI TABLET, 14 ADET, PİMREVA 200 MG FİLM KAPLI TABLET, 28 ADETEculizumab
go.drugbank.com/drugs/DB01257ApprovedInvestigational[L6919,A2245,A2246] Eculizumab was granted FDA approval on 16 March 2007. … [L6919] In Q1 2023, the EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion of two formulations of eculizumab indicated for the treatment of paroxysmal nocturnal hemoglobinuria
Products: Bekemv 300 mg/30 mL İnfüzyonluk Çözelti Hazırlamak İçin Konsantre, 1 ADET, ELİZARİA 300 MG/30 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADETGemfibrozil
go.drugbank.com/drugs/DB01241ApprovedInvestigationalGemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias. … [A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications.
Categories: Hypolipidemic Agents Indicated for Hyperlipidemia, Non-statin Hypolipidemic Agents Indicated for HyperlipidemiaProducts: LOPID 600 MG TABLET, 100 ADET, LOPID 600 MG TABLET, 30 ADETLithium carbonate
go.drugbank.com/drugs/DB14509ApprovedInvestigationalLithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label].
Categories: Drugs that are Mainly Renally Excreted with a Narrow Therapeutic IndexProducts: LITHURIL 300 MG KAPSUL, 100 ADET, LİTOMAKS 300 MG SERT KAPSÜL, 100 ADETDroperidol
go.drugbank.com/drugs/DB00450ApprovedInvestigationalVet approvedIt is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593) … A butyrophenone with general properties similar to those of haloperidol.
Categories: Adrenergic alpha-1 Receptor AntagonistsSynonyms: 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[d]imidazol-2-one, 1-(1-(3-(p-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinoneAcylcarnitine 10-Hydroxydodec-2-enedioylcarnitine
smpdb.ca/view/SMP0124030Metabolic10-Hydroxydodec-2-enedioylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, 10-hydroxydodec-2-enedioyl-CoA reacts with L-carnitine to form 10-hydroxydodec-2-enedioylcarnitine.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreAcylcarnitine (10Z)-Pentadec-10-enoylcarnitine
smpdb.ca/view/SMP0124228Metabolic(10Z)-Pentadec-10-enoylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, (10Z)-pentadec-10-enoyl-CoA reacts with L-carnitine to form (10Z)-pentadec-10-enoylcarnitine. This reaction is catalyzed by carnitine O-palmitoyltransferase.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreAcylcarnitine (10Z)-heptadec-10-enoylcarnitine
smpdb.ca/view/SMP0124309Metabolic(10Z)-heptadec-10-enoylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, (10Z)-heptadec-10-enoyl-CoA reacts with L-carnitine to form (10Z)-heptadec-10-enoylcarnitine. This reaction is catalyzed by carnitine O-palmitoyltransferase.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreAcylcarnitine (10Z)-nonadec-10-enoylcarnitine
smpdb.ca/view/SMP0124356Metabolic(10Z)-nonadec-10-enoylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, (10Z)-nonadec-10-enoyl-CoA reacts with L-carnitine to form (10Z)-nonadec-10-enoylcarnitine. This reaction is catalyzed by carnitine O-palmitoyltransferase.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreElranatamab
go.drugbank.com/drugs/DB15395ApprovedInvestigational[L47815] On August 14, 2023, the FDA granted accelerated approval to elranatamab for the treatment of multiple myeloma. … Elranatamab is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager.
Products: Elrexfio 44 mg/1,1 ml Enjeksiyonluk Çözelti, 1 ADET, Elrexfio 76 mg/1,9 ml Enjeksiyonluk Çözelti, 1 ADET