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Praziquantel
go.drugbank.com/drugs/DB01058ApprovedInvestigationalVet approved[A263201] The efficacy of praziquantel in treating parasitic flatworms infection with low cost (~US$0.20 drug cost to treat a child) makes it an integral to WHO's plan to eliminate schistosomiasis by 2030 … [A263206,A263211] Despite being approved since 1980, the exact mechanism of action is yet to be elucidated.[A263211]
Mixtures: Eqvalan Duo Oral Paste for HorseSerine/threonine-protein kinase Nek2
go.drugbank.com/bio_entities/BE0003796TargetHumansProtein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. … in their displacement from the centrosomes.
Synonyms: Never in mitosis A-related kinase 2Splicing factor 1
go.drugbank.com/bio_entities/BE0009118TargetHumansNecessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor
Synonyms: Zinc finger gene in MEN1 locusAtaluren
go.drugbank.com/drugs/DB05016ApprovedWithdrawnThis drug does not yet have approval by the US Food and Drug Administration or by Health Canada for any indications. … Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and older who are able to walk.
Glimepiride
go.drugbank.com/drugs/DB00222ApprovedInvestigational[A177703] Glimepiride was approved by the Food and Drug Administration (FDA) in the United States in 1995 for the treatment of T2DM. … First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control.
Categories: Drugs Used in DiabetesProducts: GLIMEPIRIDE SANDOZ(R) (2 MG), Co GlimepirideTelotristat ethyl
go.drugbank.com/drugs/DB12095Approved[L43342] It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt. … [A252937] Serotonin is metabolized in the urinary metabolite 5-hydroxy indole acetic acid (u5-HIAA), and high levels of u5-HIAA is associated with poor survival outcome in patients with NET.
Phenyltoloxamine
go.drugbank.com/drugs/DB11160ApprovedPhenyltoloxamine citrate is the more common salt form that acts as an active ingredient in pharmaceutical products and promotes hay fever relief via reversing the effects of histamine. … in studies as early as the 1950s) first-generation antihistamines were not optimally investigated [A32705].
Miglustat
go.drugbank.com/drugs/DB00419ApprovedInvestigationalMiglustat is now the first and only approved therapy for patients with Niemann-Pick disease type C (NP-C). … It has recently been approved for treatment of progressive neurological symptoms in adult and pediatric patients in the European Union, Brazil, and South Korea.
Synonyms: N-(n-Butyl)deoxynojirimycin, N-ButylmoranolineElafibranor
go.drugbank.com/drugs/DB05187ApprovedInvestigational[L50768] On June 10, 2024, elafibranor was granted accelerated approval by the FDA for the treatment of primary biliary cholangitis (PBC). … [L50773] The drug was also approved by the EMA on September 23, 2024.[L51878]
Golodirsen
go.drugbank.com/drugs/DB15593ApprovedInvestigational[L10773] Golodirsen was developed by Sarepta Therapeutics and granted accelerated FDA approval on December 12, 2019 due to the urgent need for this drug in patients suffering from a certain form of … This is an X-linked condition leading to progressive muscle degeneration that begins in early childhood, rendering many patients wheelchair-bound by age 12.
Categories: Compounds used in a research, industrial, or household setting