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Displaying results 2151 - 2160 of 10000 in total
  1. Target

    Outer membrane protein A

    go.drugbank.com/bio_entities/BE0002043
    TargetEscherichia coli (strain K12)

    The center of the isolated beta-barrel is polar and has a central gate (involving Glu-73, Lys-103, Glu-149 and Arg-159, sandwiched between Tyr-29, Phe-40 and Tyr-94), with no obvious passage for water … Plays a role in resistance to environmental stress, and a role in outer membrane functionality and cell shape (PubMed:11906175, PubMed:361695).

    Polypeptides: Outer membrane protein ASynonyms: Outer membrane porin A
  2. Target

    DNA gyrase subunit A

    go.drugbank.com/bio_entities/BE0003724
    TargetStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

    A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.

    Polypeptides: DNA gyrase subunit A
  3. Target

    DNA gyrase subunit A

    go.drugbank.com/bio_entities/BE0008387
    TargetBacillus subtilis (strain 168)

    A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.

    Polypeptides: DNA gyrase subunit A
  4. Target

    Inhibin beta A chain

    go.drugbank.com/bio_entities/BE0010139
    TargetHumans

    Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid

    Polypeptides: Inhibin beta A chainSynonyms: Activin beta-A chain
  5. Target

    Human Arylsulfatase A mRNA

    go.drugbank.com/bio_entities/BE0010214
    TargetHumans

  6. Target

    Interleukin-17 receptor A

    go.drugbank.com/bio_entities/BE0018249
    TargetHumans

    Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848) … Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495).

    Polypeptides: Interleukin-17 receptor ASynonyms: IL-17 receptor A
  7. Indication

    Invasive Meningococcal Infection caused by Neisseria meningitidis serogroup Y

    go.drugbank.com/conditions/DBCOND0093729
    Drugs: Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine · Meningococcal polysaccharide vaccine group Y · Neisseria meningitidis group A capsular polysaccharide tetanus toxoid conjugate antigen · Neisseria meningitidis group y capsular polysaccharide diphtheria toxoid conjugate antigen
    Synonyms: Invasive Infection caused by Neisseria meningitidis serogroup Y, Invasive Meningococcal Infection caused by Neisseria meningitidis serogroup Y
  8. Drug

    Vinflunine

    go.drugbank.com/drugs/DB11641
    ApprovedInvestigational

    Like other vinca agents, vinflunine is an anti-mitotic agent that induces a cell cycle arrest at the G2/M phase and promotes cell death via apoptosis [L1396]. … In 2009, vinflunine was approved by the European Medicines Agency (EMA) as a second-line therapy of metastatic and advanced urothelial cancer after failure of platinum-based treatment [A32626].

    Synonyms: 20',20'-difluoro-3',4'-dihydrovinorelbine, 4'-deoxy-20',20'-difluoro-5'-norvincaleukoblastineCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
  9. Drug

    Prednisolone hemisuccinate

    go.drugbank.com/drugs/DB14633
    Investigational

    Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersProducts: Prednisolut 100 mg Pulver und Lösungsmittel zur Herstellung einer Injektions-/Infusionslösung, Solu-Dacortin 1 g - Pulver und Lösungsmittel zur Herstellung einer Injektionslösung oder Infusionslösung
  10. Indication

    Chronic Motor and Vocal Tic Disorder

    go.drugbank.com/conditions/DBCOND0082272
    Drugs: Aripiprazole
    Synonyms: Gilles de la Tourette, Gilles de La Tourette's Disease