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Displaying results 2231 - 2240 of 10000 in total
  1. Target

    Acyl-coenzyme A thioesterase 13

    go.drugbank.com/bio_entities/BE0004376
    TargetHumans

    May play a role in controlling adaptive thermogenesis (By similarity) … Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16934754, PubMed:19170545).

    Polypeptides: Acyl-coenzyme A thioesterase 13
  2. Target

    Ras-related protein Ral-A

    go.drugbank.com/bio_entities/BE0004562
    TargetHumans

    Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. … Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108).

    Polypeptides: Ras-related protein Ral-A
  3. Target

    Serum amyloid A-1 protein

    go.drugbank.com/bio_entities/BE0004795
    TargetHumans

    Major acute phase protein

    Polypeptides: Serum amyloid A-1 protein
  4. Target

    Ephrin type-A receptor 3

    go.drugbank.com/bio_entities/BE0009437
    TargetHumans

    Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5 (By similarity). … Also activated by EFNA1, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development (PubMed:12794130). Involved in the retinotectal mapping of neurons.

    Polypeptides: Ephrin type-A receptor 3
  5. Target

    Ephrin type-A receptor 6

    go.drugbank.com/bio_entities/BE0009439
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.

    Polypeptides: Ephrin type-A receptor 6
  6. Target

    GABA-A gated chloride channel

    go.drugbank.com/bio_entities/BE0009556
    TargetOnchocerca volvulus

  7. Target

    ATP-dependent RNA helicase A

    go.drugbank.com/bio_entities/BE0014303
    TargetHumans

    Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, … Plays a role in mRNA translation (PubMed:28355180).

    Polypeptides: ATP-dependent RNA helicase ASynonyms: RNA helicase A
  8. Drug

    Sambucus nigra flowering top

    go.drugbank.com/drugs/DB11247
    ApprovedWithdrawn

    Synonyms: European elder flowering top, European black elderberry flowering top
  9. Drug

    Dutasteride

    go.drugbank.com/drugs/DB01126
    ApprovedInvestigational

    It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. … [A1909] Type I and II 5α-reductase enzymes convert testosterone into dihydrotestosterone (DHT), a primary hormonal mediator that plays a role in the development and enlargement of the prostate gland.

    Mixtures: DUODART 0,5 MG/0,4 MG KAPSÜL,7 KAPSÜL, Duodart 0,5 mg/0,4 mg HartkapselnCategories: 5-alpha Reductase Inhibitors, Cytochrome P-450 Substrates
  10. Drug

    Sodium fluoride

    go.drugbank.com/drugs/DB09325
    ApprovedInvestigational

    Sodium fluoride is an inorganic chemical compound that is a source of the fluoride ion in many applications, including dental care and radiographic imaging when it is used as [Fluoride ion F-18]. … Now, sodium fluoride may be found in a variety of gels, varnishes, rinses, toothpaste products, and fluoride treatments provided in dental care.

    Mixtures: TRACUTIL® 10 ML AMPOLLAS, Multivitamin with 1.0 mg FluorideCategories: Compounds used in a research, industrial, or household setting