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Solifenacin
go.drugbank.com/drugs/DB01591ApprovedInvestigationalSolifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was g...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesThiothixene
go.drugbank.com/drugs/DB01623ApprovedA thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesLincomycin
go.drugbank.com/drugs/DB01627ApprovedInvestigationalVet approvedLincomycin is a lincosamide antibiotic first isolated from the soil bacterium Streptomyces lincolnensis in Lincoln, Nebraska. Clinical use of lincomycin has largely been superseded by its semisynthetic derivative clindamycin due to its h...
Genistein
go.drugbank.com/drugs/DB01645InvestigationalAn isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce ...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesPrasterone
go.drugbank.com/drugs/DB01708ApprovedInvestigationalNutraceuticalPrasterone, also known as dehydroepiandrosterone (DHEA) is a major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testost...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsDigoxigenin
go.drugbank.com/drugs/DB03671ExperimentalDigoxigenin is a cardenolide which is the aglycon of digoxin. Can be obtained by hydrolysis of digoxin or from Digitalis orientalis L. and Digitalis lanata Ehrh.
Categories: P-glycoprotein substratesBerberine
go.drugbank.com/drugs/DB04115ApprovedInvestigationalWithdrawnAn alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal.
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP1A2 InhibitorsQuercetin
go.drugbank.com/drugs/DB04216InvestigationalQuercetin is a flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP1A2 InhibitorsCholesterol
go.drugbank.com/drugs/DB04540ApprovedInvestigationalWithdrawnThe principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Categories: P-glycoprotein inhibitors