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Displaying results 2261 - 2270 of 10000 in total
  1. Pathway

    NAD+ Signalling and Aging

    smpdb.ca/view/SMP0084271
    Signaling

    In support of such a mechanism, mutation or reduced function in nuclear genes encoding ETC components in yeast, Caenorhabditis elegans, Drosophila, and mice increase life span through activation of the … NAD salvage pathway is deficient in aging since the supplementation with NMN corrects defects associated with aging.

    Drugs: 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · Nicotinamide · Flavin adenine dinucleotide
  2. Drug

    Garetosmab

    go.drugbank.com/drugs/DB16379
    ApprovedInvestigational

    [L63940] It is a fully human IgG4 monoclonal antibody that binds and neutralizes activin A, blocking activin A from activating the mutant ACVR1 receptor that, in FOP, drives the formation of heterotopic … [L63940] Garetosmab-grts was approved by the FDA on August 19, 2026 to reduce the number of new heterotopic ossification lesions and clinician-assessed flare-ups in adults with FOP.

  3. Drug

    Imipenem

    go.drugbank.com/drugs/DB01598
    ApprovedInvestigational

    [A15389] Imipenem is commonly used in combination with [cilastatin] and is now available in a triple-drug product with cilastatin and [relebactam] which was recently approved by the FDA. … [label] It is stable to many beta-lactamases.

    Mixtures: TIENAM 500 MG IV ENJEKTABL FLAKON, 1 ADET, VIAPENEM 500 MG/500 MG IV İNFÜZYON İÇİN KURU TOZ İÇEREN FLAKON, 1 ADETCategories: Heterocyclic Compounds, 2-Ring
  4. Drug

    Navepegritide

    go.drugbank.com/drugs/DB17824
    ApprovedInvestigational

    [L56065] Navepegritide was approved by the US FDA in February 2026 for use in patients 2 years of age and older with achondroplasia with open epiphyses.[L56058,L56065] … Achondroplasia, the most prevalent skeletal dysplasia, is caused by a gain-of-function variant in the fibroblast growth factor receptor 3 (FGFR3), which leads to overactive downstream signaling that inhibits

  5. Drug

    Zinc citrate

    go.drugbank.com/drugs/DB11154
    ApprovedInvestigational

    Zinc citrate is a zinc salt of citric acid. It is available as dietary supplements as a treatment of zinc deficiency and source of zinc, which is an essential trace element.

    Mixtures: Calcium-magnesium With K & Zn and Vitamin D3, Dialyvite Supreme DCategories: Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
  6. Drug

    Abacavir

    go.drugbank.com/drugs/DB01048
    ApprovedInvestigational

    In vivo, abacavir sulfate dissociates to its free base, abacavir. … Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring.

    Mixtures: ABACAVIR E LAMIVUDINA DOC GENERICI, N/ACategories: Antivirals used in combination for the treatment of HIV infections, Heterocyclic Compounds, 2-Ring
  7. Drug

    Ceritinib

    go.drugbank.com/drugs/DB09063
    ApprovedInvestigational

    The FDA approved ceritinib in April 2014 due to a surprisingly high response rate (56%) towards crizotinib-resistant tumours and has designated it with orphan drug status. … results in constitutive kinase activity that contributes to carcinogenesis and seems to drive the malignant phenotype.

    Synonyms: N-{2-[(5-chloro-2-{[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propane-2-sulfonamideCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
  8. Drug

    Gadoxetic acid

    go.drugbank.com/drugs/DB08884
    ApprovedInvestigational

    Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. … Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up the drug.

    Categories: Compounds used in a research, industrial, or household setting, Diagnostic Uses of ChemicalsProducts: PRIMOVIST® SOLUCIÓN INYECTABLE, PRIMOVIST 0,25 MMOL/ML ENJEKSIYON ICIN COZELTI ICEREN KULLANIMA HAZIR ENJEKTOR, 1 ADET
  9. Drug

    Bifonazole

    go.drugbank.com/drugs/DB04794
    Approved

    Bifonazole is an azole antifungal drug.

    Synonyms: (+-)-1-(p,alpha-Diphenylbenzyl)imidazole, 1-(p,alpha-Diphenylbenzyl)imidazoleMixtures: CANESTEN ULTRA UÑAS 1%
  10. Drug

    Technetium Tc-99m pertechnetate

    go.drugbank.com/drugs/DB09314
    ApprovedInvestigational

    This is normally supplied in a hospital setting through the use of a technetium-99m generator, whereby technetium exits the generator in the form of the pertechnetate ion, TcO4−, which can be extracted … However, in contrast to the iodide ion, the pertechnetate ion is released unchanged from the thyroid gland.

    Mixtures: GENERADOR DE SOLUCION INYECTABLE DE PERTECNETATO (99MTC) DE SODIO. 2-50GBQ, TECHNELITE® GENERADOR DE TECNECIO TC 99MCategories: Compounds used in a research, industrial, or household setting, Diagnostic Uses of Chemicals