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Displaying results 2261 - 2270 of 3729 in total
  1. Drug

    Protriptyline

    go.drugbank.com/drugs/DB00344
    Approved

    , alpha<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention

    Categories: P-glycoprotein inhibitors
  2. Drug

    Nitisinone

    go.drugbank.com/drugs/DB00348
    Approved

    Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1 and Alkaptonuria. It is sold under the brand names Orfadin and Harliku.

    Synonyms: 2-(alpha,alpha,alpha-Trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedioneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  3. Drug

    Methylergometrine

    go.drugbank.com/drugs/DB00353
    ApprovedInvestigational

    A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed)

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitors
  4. Drug

    Aminoglutethimide

    go.drugbank.com/drugs/DB00357
    ApprovedWithdrawn

    An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced...

    Synonyms: p-Aminoglutethimide, 2-(p-Aminophenyl)-2-ethylglutarimideCategories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP2C19 Inducers
  5. Drug

    Dydrogesterone

    go.drugbank.com/drugs/DB00378
    ApprovedInvestigationalWithdrawn

    A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  6. Drug

    Mexiletine

    go.drugbank.com/drugs/DB00379
    ApprovedInvestigational

    Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inhibitors
  7. Drug

    Nisoldipine

    go.drugbank.com/drugs/DB00401
    Approved

    Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in s...

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  8. Drug

    Remoxipride

    go.drugbank.com/drugs/DB00409
    ApprovedWithdrawn

    Remoxipride is an atypical antipsychotic agent that is specific for dopamine D2 receptors. It gained approval in the UK in 1989 but was withdrawn in 1993 after it was found to be associated with an increased incidence of aplastic anemia.

    Categories: Dopamine D2 Receptor Antagonists, Cytochrome P-450 Substrates
  9. Drug

    Ampicillin

    go.drugbank.com/drugs/DB00415
    ApprovedInvestigationalVet approved

    Ampicillin is a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.

  10. Drug

    Entecavir

    go.drugbank.com/drugs/DB00442
    ApprovedInvestigational

    Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS). Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and ...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates