Search

Displaying results 2301 - 2310 of 10000 in total
  1. Drug

    Eltrombopag

    go.drugbank.com/drugs/DB06210
    ApprovedInvestigational

    Eltrombopag has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based … ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood.

    Categories: Thrombopoietin Receptor Agonist, Thrombopoietin Receptor AgonistsProducts: REVOLADE® TABLETAS 25 MG, REVOLADE ® TABLETAS 50 MG
  2. Drug

    Strontium chloride

    go.drugbank.com/drugs/DB13987
    ApprovedWithdrawn

    Strontium chloride (SrCl2) is a salt of strontium and chloride. … This kind of barrier protection for tooth hypersensitivity has, however, been superseded by other toothpaste formulations and ingredients designed to be nerve calming agents instead [A33167, A33168].

    Products: METASTRON®
  3. Drug

    Butropium

    go.drugbank.com/drugs/DB15968
    Experimental

  4. Drug

    LB-001

    go.drugbank.com/drugs/DB17685
    Experimental

    LB-001 is a gene editing therapy designed to incorporate a functioning version of the faulty methylmalonyl-COA mutase (MUT) gene into the genome of patients with methylmalonic acidemia.

  5. Drug

    AP103

    go.drugbank.com/drugs/DB18234
    Experimental

    AP103 is a non-viral gene therapy that uses a delivery vector, HPAE (Highly Branched Poly β-Amino Ester), to deliver the correct collagen VII gene into skin cells.

  6. Target

    Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2

    go.drugbank.com/bio_entities/BE0009594
    TargetHumans

    Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is ...

    Synonyms: IP3 receptor isoform 2, Type 2 InsP3 receptor
  7. Drug

    EPC2407

    go.drugbank.com/drugs/DB05189
    Investigational

    EPC2407 is a novel small molecule vascular disruption agent and apoptosis inducer for the treatment of patients with advanced solid tumors and lymphomas.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  8. Target

    Ras-related C3 botulinum toxin substrate 1

    go.drugbank.com/bio_entities/BE0001109
    TargetHumans

    Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its … In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization

    Synonyms: Cell migration-inducing gene 5 protein
  9. Target

    DNA helicase/primase

    go.drugbank.com/bio_entities/BE0001811
    TargetEnterobacteria phage T7

    ATP-dependent DNA helicase and primase essential for viral DNA replication and recombination (PubMed:21606333, PubMed:22977246, PubMed:32009150). The helicase moves 5' -> 3' on the lagging strand template, unwinding the DNA duplex ahead ...

    Synonyms: Gene product 4
  10. Drug

    Umifenovir

    go.drugbank.com/drugs/DB13609
    Investigational

    [A191475] It has been in use in Russia for approximately 25 years and in China since 2006. … , including _Flavivirus_,[A191388] Zika virus,[A191391] foot-and-mouth disease,[A191394] Lassa virus,[A191403] Ebola virus,[A191403] herpes simplex,[A191409], hepatitis B and C viruses, chikungunya virus

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates