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Deutetrabenazine
go.drugbank.com/drugs/DB12161ApprovedInvestigationalDecreased plasma fluctuations of deutetrabenazine due to attenuated metabolism may explain a lower incidence of adverse reactions associated with deutetrabenazine [A32042]. … As with other agents for the treatment of neurodegenerative diseases, deutetrabenazine is a drug to alleviate the motor symptoms of HD and is not proposed to halt the progression of the disease [T28].
Synonyms: D6 tetrabenazine, D6-tetrabenazineAcitretin
go.drugbank.com/drugs/DB00459ApprovedInvestigationalAn oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Categories: Retinoids for Treatment of PsoriasisTropisetron
go.drugbank.com/drugs/DB11699ApprovedInvestigationalWithdrawnAs a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting … Tropisetron is an indole derivative with antiemetic activity.
Rabies immune globulin, human
go.drugbank.com/drugs/DB11603ApprovedIf IMOGAM Rabies Pasteurized is not administered as recommended at the initiation of the post-exposure rabies vaccine series, it can be administered up to eight days following the first dose of the rabies … Recommendations for passive and/or active immunization after exposure to an animal suspected of having rabies have been outlined by the National Advisory Committee on Immunization (NACI), the Advisory
Products: EQUIRAB 1000 IU/5ML IM/SC ÇÖZELTI IÇEREN FLAKON, 1 ADET, Hyperrab S/dCyproheptadine
go.drugbank.com/drugs/DB00434ApprovedInvestigationalCyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. … [L32474] It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation[L32519] and its off-label use in the treatment of serotonin syndrome.
Synonyms: 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine, 4-Dibenzo[a,d]cyclohepten-5-ylidene-1-methyl-piperidineBevacizumab
go.drugbank.com/drugs/DB00112ApprovedInvestigational[A286054] This off-label practice was formalized with the approval of Lytenava (bevacizumab-vikg in the US; bevacizumab gamma in the EU/UK), the first ophthalmic formulation of bevacizumab developed specifically … There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important for the survival and proliferation of cancer cells.
International brands: Ai Rui TuoVonoprazan
go.drugbank.com/drugs/DB11739ApprovedInvestigationalPCABs represent an alternative to proton-pump inhibitors for the treatment of acid-related disorders. … [A253702] In May 2022, the FDA approved the use of vonoprazan in a co-packaged product containing amoxicillin and clarithromycin for the treatment of _H. pylori_ infection.
Naldemedine
go.drugbank.com/drugs/DB11691ApprovedInvestigationalIt is a modified form of [DB00704] to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. … Naldemedine is an opioid receptor antagonist [FDA Label].
Categories: Heterocyclic Compounds with 4 or More RingsGadolinium
go.drugbank.com/drugs/DB12091ApprovedInvestigationalWithdrawnGadolinium has been investigated for the basic science of CAD, Multiple Sclerosis, and Coronary Artery Disease.
Categories: Compounds used in a research, industrial, or household setting, Diagnostic Uses of ChemicalsDP-b99
go.drugbank.com/drugs/DB05820InvestigationalDP-b99 is a newly developed lipophilic, cell permeable derivative of BAPTA (1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid), that is under development as a neuroprotectant for the potential treatment … of stroke, head trauma and neurological damage associated with coronary artery bypass graft.