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Displaying results 231 - 240 of 2821 in total
  1. Drug

    Tralokinumab

    go.drugbank.com/drugs/DB12169
    ApprovedInvestigational

    [A242427] Tralokinumab is a fully human IgG4 monoclonal antibody targeted against IL-13. … It neutralizes IL-13 activity by inhibiting its ability to bind with receptors, thus helping to alleviate AD symptoms.

  2. Drug

    Reslizumab

    go.drugbank.com/drugs/DB06602
    ApprovedInvestigational

    IL-5 is a pro-inflammatory cytokine that is responsible for the growth and differentiation, recruitment, activation, and survival of eosinophils [FDA Label]. … By targeting the IL-5 and disrupting its signalling pathways, reslizumab aims to inhibit eosinophil maturation and promote programmed cell death [A31578].

  3. Drug

    Camphor

    go.drugbank.com/drugs/DB01744
    ApprovedInvestigationalWithdrawn

    When ingested, camphor has a rapid onset of toxic effects, and camphorated oil is the product most often responsible for its toxicity. … The FDA ruled that camphorated oil could not be marketed in the United States and that no product could contain a concentration higher than 11%.

    Mixtures: Pain Relieving Po Tong Oil, Sarna PSynonyms: Camphor oil
  4. Drug

    Rilonacept

    go.drugbank.com/drugs/DB06372
    ApprovedInvestigational

    Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1.

    Synonyms: IL-1 TRAP, IL-1-TRAP
  5. Drug

    Trolamine

    go.drugbank.com/drugs/DB13747
    ApprovedInvestigational

    It is commonly used as a pH adjuster and surfactant in industrial and cosmetic products such as skin and hair conditioning products.

    Mixtures: Calenda-cucumber Oil-free Moisturizer
  6. Target

    Immunoglobulin heavy variable 3-23

    go.drugbank.com/bio_entities/BE0004165
    TargetHumans

    V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocy...

    Synonyms: Ig heavy chain V-III region TIL
  7. Drug

    Avelumab

    go.drugbank.com/drugs/DB11945
    ApprovedInvestigational

    Avelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) to block its interaction with its receptors found on T cells and antigen-presenting cells.

    Categories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors
  8. Drug

    Aluminum chlorohydrate

    go.drugbank.com/drugs/DB11573
    Approved

    Aluminum chlorohydrate is a group of water-soluble aluminum complexes with the general formula AlnCl(3n-m)(OH)m. It is included up to 25% in over-the-counter hygiene products as an active antiperspirant agent. The primary site of action ...

    Products: Secret Outlast Dry Argan Oil, Secret Weightless Dry Vanilla plus Argan Oil
  9. Drug

    Adenosine

    go.drugbank.com/drugs/DB00640
    ApprovedInvestigational

    The structure of adenosine was first described in 1931, though the vasodilating effects were not described in literature until the 1940s. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy, though i...

    Mixtures: Seamoms Tamanu Oil Mist, rep Nutrinature Ultra Moist Gel OilCategories: Purinergic P1 Receptor Agonists
  10. Drug

    Ixekizumab

    go.drugbank.com/drugs/DB11569
    ApprovedInvestigational

    Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. … In particular, IL-17A has been found to be implicated in a variety of autoimmune diseases including Rheumatoid Arthritis and plaque psoriasis.