Identification
- Summary
Aluminum chlorohydrate is a compound used as an antiperspirant.
- Generic Name
- Aluminum chlorohydrate
- DrugBank Accession Number
- DB11573
- Background
Aluminum chlorohydrate is a group of water-soluble aluminum complexes with the general formula AlnCl(3n-m)(OH)m. It is included up to 25% in over-the-counter hygiene products as an active antiperspirant agent. The primary site of action of aluminum chlorohydrate is at the level of the stratum corneum layer, which is relatively near the skin surface 1. It is also used as a coagulant in the water purification process.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Aluminum chlorohydrate (DB11573)
- Weight
- Average: 192.46
Monoisotopic: 191.9561926 - Chemical Formula
- Al2ClH7O6
- Synonyms
- Alchlordrate
- Aluminium chlorohydrate
- Aluminum chlorhydrate
- Aluminum chlorohydrate
- Aluminum chlorohydrate dihydrate
- Aluminum hydroxychloride
- External IDs
- DA-1097
Pharmacology
- Indication
Indicated for use as an antiperspirant.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Aluminum chlorohydrate serves to reduce excessive sweating by directly blocking the sweat ducts 4.
- Mechanism of action
Aluminum salts plug eccrine sweat pores and forms aggregates with swear proteins that bind to the wall of the sweat duct and form a tenuous membrane 4.
- Absorption
Penetration of aluminum chlorohydrate following dermal application is minimal, with the rate being around 0.01% and up to 0.06% in pre-damaged skin 3. In a preliminary study, dermally applied aluminium chlorohydrate displayed 0.012% of the applied aluminium being absorbed through the skin, which accounts for 4 mcg of aluminum following a single dermal application 2. This is about 2.5% of the aluminium typically absorbed by the gut from food over the same time period 2.
- Volume of distribution
No pharmacokinetic information available.
- Protein binding
No pharmacokinetic information available.
- Metabolism
No pharmacokinetic information available.
- Route of elimination
No pharmacokinetic information available.
- Half-life
No pharmacokinetic information available.
- Clearance
No pharmacokinetic information available.
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Dermal and oral LD50 in rat is > 2000 mg/kg MSDS.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareChenodeoxycholic acid Aluminum chlorohydrate can cause a decrease in the absorption of Chenodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy. Cholic Acid Aluminum chlorohydrate can cause a decrease in the absorption of Cholic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy. Dehydrocholic acid Aluminum chlorohydrate can cause a decrease in the absorption of Dehydrocholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy. Deoxycholic acid Aluminum chlorohydrate can cause a decrease in the absorption of Deoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy. Dolutegravir The serum concentration of Dolutegravir can be decreased when it is combined with Aluminum chlorohydrate. Halofantrine Aluminum chlorohydrate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy. Obeticholic acid Aluminum chlorohydrate can cause a decrease in the absorption of Obeticholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy. Ox bile extract The serum concentration of Ox bile extract can be decreased when it is combined with Aluminum chlorohydrate. Phenytoin Aluminum chlorohydrate can cause a decrease in the absorption of Phenytoin resulting in a reduced serum concentration and potentially a decrease in efficacy. Roxadustat Aluminum chlorohydrate can cause a decrease in the absorption of Roxadustat resulting in a reduced serum concentration and potentially a decrease in efficacy. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Active Moieties
Name Kind UNII CAS InChI Key Aluminum cation ionic 3XHB1D032B 22537-23-1 REDXJYDRNCIFBQ-UHFFFAOYSA-N - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 2.25OZ EverDry Ultra Dry Antiperspirant Stick 20 g/100g Topical American Consumer Products Corp 2019-09-17 Not applicable US 
2.5OZ EverDry Antiperspirant Invisible Stick 20 g/100g Topical American Consumer Products Corp 2019-09-17 Not applicable US 5 Day Liquid 0.25 g/1 Topical Numark Brands, Inc 1937-04-10 Not applicable US Above Dermaclinical Men 72 hours Cream 12 mg/100g Topical Baston Industria de Aerossóis Ltda 2022-11-14 Not applicable US Above Elements Antibac Shinysilver Cream 12 mg/100g Topical Baston Industria de Aerossóis Ltda 2022-11-14 Not applicable US Above Men Elements Ocean Invisible Cream 12 mg/100g Topical Baston Industria de Aerossóis Ltda 2022-11-14 Not applicable US Above Men Sport Energy Cream 50 mg/100g Topical Baston Industria de Aerossóis Ltda 2022-11-14 Not applicable US Above Women Derma Clinical 72 H Cream 12 mg/100g Topical Baston Industria de Aerossóis Ltda 2022-11-14 Not applicable US Above Women Personalities Fierce and Savage Cream 12 mg/100g Topical Baston Industria de Aerossóis Ltda 2022-11-14 Not applicable US ABOVE WOMEN PERSONALITIES PEACEFUL and FASHION Cream 12 mg/100g Topical Baston Industria de Aerossóis Ltda 2022-11-14 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Akileine Vaporisateur Antitranspirant Aluminum chlorohydrate (50 mg / mL) + Ethanol (600 mg / mL) Spray Topical Laboratoire Larima ltÉe 1985-12-31 2007-07-31 Canada 
Anti-perspirant Roll-ON Deod Aluminum chlorohydrate (20 %) + Aluminum chloride (2 %) Liquid Topical Estee Lauder Dist 1987-12-31 2002-07-31 Canada Arrid Cream Aluminum chlorohydrate (21.2 %) + Aluminum chloride (1 %) Cream Topical Carter Products, Division Of Carter Wallace Ns Inc. 1939-12-31 1999-09-27 Canada Ban Ultra Antiperspirant Roll-ON Aluminum chlorohydrate (12 %) + Aluminum zirconium tetrachlorohydrex gly (12 %) Liquid Topical Jergens Canada Inc. 1999-12-30 2002-07-15 Canada KURSEPT %19 + %1 KREM (30 G) Aluminum chlorohydrate (19 %) + Triclosan (1 %) Cream Topical ORVA İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey 
Lactovit DEO ROLL ON LACTOUREA DEODORANT ANTIPERSPIRANT Aluminum chlorohydrate (6.4 mg/1) + Aluminum sesquichlorohydrate (0.808 mg/1) Liquid Topical Laboratorios Genesse Sl 2016-11-19 2017-12-31 US Lactovit DEO ROLL-ON LACTOUREA DEODORANT ANTIPERSPIRANT Aluminum chlorohydrate (6.4 mg/1mL) + Aluminum sesquichlorohydrate (0.6464 mg/1mL) Liquid Topical Laboratorios Genesse Sl 2016-11-19 2017-12-31 US Lactovit Mens Roll On Antiperspirant Deodorant Aluminum chlorohydrate (9.6 mg/1) + Aluminum sesquichlorohydrate (0.9696 mg/1) Liquid Topical Laboratorios Genesse Sl 2016-11-19 2017-12-31 US Lactovit Original Roll-On Antiperspirant Deodorant Aluminum chlorohydrate (11.2 mg/1) + Aluminum sesquichlorohydrate (1.1312 mg/1) Liquid Topical Laboratorios Genesse Sl 2016-11-23 2017-12-31 US Medif White Tooth Aluminum chlorohydrate (0.65 g/130g) + Allantoin (0.65 g/130g) + Silicic acid (16.90 g/130g) Paste, dentifrice Oral Medif Co.,Ltd 2020-10-01 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Medif White Tooth Aluminum chlorohydrate (0.65 g/130g) + Allantoin (0.65 g/130g) + Silicic acid (16.90 g/130g) Paste, dentifrice Oral Medif Co.,Ltd 2020-10-01 Not applicable US
Categories
- ATC Codes
- D09AA08 — Aluminium chlorohydrate
- D09AA — Medicated dressings with antiinfectives
- D09A — MEDICATED DRESSINGS
- D09 — MEDICATED DRESSINGS
- D — DERMATOLOGICALS
- Drug Categories
- Alkalies
- Aluminium Compounds
- Anions
- Astringents and Deodorants
- Dermatologicals
- Drugs Affecting Bone Structure and Mineralization
- Drugs for Treatment of Bone Diseases
- Electrolytes
- Hydroxides
- Ions
- Medicated Dressings
- Medicated Dressings With Antiinfectives
- Metal cations
- Metal divalent cations
- Musculo-Skeletal System
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as post-transition metal hydroxides. These are inorganic compounds in which the largest oxoanion is hydroxide, and in which the heaviest atom not in an oxoanion is a post-transition metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Post-transition metal oxoanionic compounds
- Sub Class
- Post-transition metal hydroxides
- Direct Parent
- Post-transition metal hydroxides
- Alternative Parents
- Post-transition metal salts / Inorganic oxides / Inorganic hydrides / Inorganic chloride salts
- Substituents
- Inorganic chloride salt / Inorganic hydride / Inorganic oxide / Inorganic post-transition metal salt / Inorganic salt / Post-transition metal hydroxide
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- HPN8MZW13M
- CAS number
- 12359-72-7
- InChI Key
- ZLVPDILYQLCEJO-UHFFFAOYSA-H
- InChI
- InChI=1S/2Al.ClH.6H2O/h;;1H;6*1H2/q2*+3;;;;;;;/p-6
- IUPAC Name
- dialuminium(3+) ion hydrate chloride pentahydroxide
- SMILES
- O.[OH-].[OH-].[OH-].[OH-].[OH-].[Al+3].[Al+3].[Cl-]
References
- General References
- Quatrale RP, Coble DW, Stoner KL, Felger CB: The mechanism of antiperspirant action by aluminum salts. II. Histological observations of human eccrine sweat glands inhibited by aluminum chlorohydrate Journal of the Society of Cosmetic Chemists. 1981 Jan 1;32(3):107-136. [Article]
- Flarend R, Bin T, Elmore D, Hem SL: A preliminary study of the dermal absorption of aluminium from antiperspirants using aluminium-26. Food Chem Toxicol. 2001 Feb;39(2):163-8. [Article]
- Klotz K, Weistenhofer W, Neff F, Hartwig A, van Thriel C, Drexler H: The Health Effects of Aluminum Exposure. Dtsch Arztebl Int. 2017 Sep 29;114(39):653-659. doi: 10.3238/arztebl.2017.0653. [Article]
- Bretagne A, Cotot F, Arnaud-Roux M, Sztucki M, Cabane B, Galey JB: The mechanism of eccrine sweat pore plugging by aluminium salts using microfluidics combined with small angle X-ray scattering. Soft Matter. 2017 May 24;13(20):3812-3821. doi: 10.1039/c6sm02510b. [Article]
- DailyMed: Amerfresh Roll-on Antiperspirant [Link]
- External Links
- PubChem Compound
- 71586946
- PubChem Substance
- 347827987
- ChemSpider
- 32699791
- 17610
- Wikipedia
- Aluminium_chlorohydrate
- MSDS
- Download (333 KB)
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Liquid Topical 0.25 g/1 Cream Topical 12 mg/100g Cream Topical 50 mg/100g Spray Topical Liquid Topical 10 mg/1mL Solution Topical 18 % Lotion Topical 17.5 % Solution Topical 10 mg/100mL Spray Topical 13 mg/100mL Spray Topical 13 g/100mL Spray Topical 130 mg/1mL Stick Topical 52 mg/1g Stick Topical 11.4 1/57g Aerosol, spray Topical 16 g/100g Aerosol, spray Topical 100 g/100g Stick Topical 23 g/100g Liquid Topical 15 mL/100mL Lotion Topical 250 mg/1mL Liquid Topical 12.3 g/100mL Aerosol, spray Topical 23 g/100g Liquid Topical 22 % Swab Topical 15 g/100g Liquid Topical 182 mg/1mL Liquid Topical 10 g/100mL Cream Topical 150 mg/75g Aerosol Topical 18 % Aerosol Topical 12.5 % Lotion Topical 20 % Stick Topical 30 % Aerosol, spray Topical 24.6 g/1g Aerosol, spray Topical 0.246 g/1g Stick Topical 0.19 g/1g Aerosol, spray Topical 246 mg/1g Aerosol, spray Topical 250 mg/1g Liquid Topical 16 1/100mL Lotion Topical 25 g/100g Lotion Topical 16 g/100g Liquid Topical 100 mg/1mL Lotion Topical 25 % Stick Topical 25 % Aerosol, spray Topical 23.3 g/100g Liquid Topical 18 g/100mL Liquid Topical 20 g/103mL Spray Topical 3.78 g/200g Liquid Topical 250 mg/1mL Spray Topical 15 % Aerosol Topical 9.2 % Aerosol Topical 20.9 g/100g Aerosol Topical 8.8 g/100g Spray Topical 25 g/100mL Gel Topical 7.8 mL/100mL Stick Topical 7.8 g/100g Liquid Topical 140 mg/1mL Stick Topical 18 % Stick Topical 18 g/100g Liquid Topical 70 mL/100mL Gel Topical 207 mg/1mL Spray Topical 12 g/125g Liquid Topical 25 mL/100mL Spray Topical 7.90 mL/100mL Gel Topical 150 mg/1mL Gel Topical 45 mg/1mL Liquid Topical 45 mg/1mL Liquid Topical 79 mg/1mL Lotion Topical 45 mg/1mL Lotion Topical 78 mg/1mL Solution Topical 78 mg/100mL Stick Topical 9.2 g/64g Stick Cutaneous 14.4 1/1 Aerosol Topical 8.8 % Aerosol Topical 10 % Spray Topical 10.95 % Aerosol, spray Topical 19.1 g/100g Aerosol, spray Topical 8.8 g/100g Cream Topical 12.5 g / 100 g Suspension Topical 15 g / 100 g Spray Topical 3 g/100mL Liquid Topical 15.5 % Stick Topical 15 % Lotion Topical 155 mg/1mL Aerosol, spray Intradermal; Topical 0.24 g/1g Aerosol Topical 9.9 % Aerosol Topical 13.4 % Stick Topical 19.6 g/100g Aerosol, spray Topical 20.2 g/100g Liquid Topical 17.5 % Liquid Topical 144 mg/1mL Cream Topical 200 mg/1g Gel Topical 20 g/100g Liquid Topical 0.045 g/1mL Spray Topical 0.045 g/1mL Spray Topical 30 g/150mL Spray Topical 78 mg/1mL Stick Topical 20 % Lotion Topical 160 mg/1mL Gel Topical 7.25 mL/50mL Gel Topical 13.5 g/60mL Emulsion Topical 150 mg/1mL Liquid Topical 15 g/100g Liquid Topical 0.25 g/1mL Spray Topical 0.13 g/1g Liquid Topical 0.1 g/1g Stick Topical 0.16 g/1g Cloth Topical 0.2 mg/1mL Liquid Topical 100 g/100mL Lotion Topical 11 g/50g Liquid Topical 78 mg/1mL Liquid Topical 0.18 g/1mL Gel Topical 145 mg/1mL Stick Topical 1 g/100g Liquid Topical 200 mg/1mL Lotion Topical 12.3 g/100g Liquid Topical 160 mg/1mL Liquid Topical 22.5 % Stick Topical 15 g/75g Lotion Topical 120 mg/1mL Stick Topical 200 mg/1g Cream Topical 128 mg/1mL Cloth Topical 0.15 g/1g Kit Topical 140 mg/1mL Cream Topical 100 mg/1mL Cream Topical 63 mg/1mL Cream Topical 120 mg/1mL Liquid Topical Liquid Topical 15 mg/100mL Cream Topical 140 mg/1mL Liquid Topical 150 mg/1mL Liquid Topical 10 mg/100mL Liquid Topical 10 mL/100mL Cream Topical 80 mg/1mL Aerosol, spray Topical 0.24 g/1mL Spray Cutaneous 3 mL/100mL Cream Topical 20 % Paste, dentifrice Oral Liquid Topical 4.5 g/100mL Aerosol Topical 0.25 g/1mL Cream Topical Cream Topical 20.06 % Stick Topical 0.23 g/1g Lotion Topical 22.5 % Lotion Topical Lotion Topical 100 mg/ml Liquid Topical 12.5 g/100mL Liquid Topical 180 mg/1mL Stick Topical 15 g/100g Solution Topical 15 g/100g Liquid Topical 15 g/100mL Liquid Topical 20 g/100mL Aerosol, spray Topical 25 g/100g Aerosol, spray Topical 0.23 g/1g Spray Topical 24.1 g/100g Liquid Topical 14 g/100mL Gel Topical 5.67 g/56.7g Gel Topical Spray Topical 20.2 g/100g Spray Topical 9.05 g/45g Liquid Topical 16 % Emulsion Topical 200 mg/1g Aerosol Topical 9.5 % / g Aerosol, spray Topical 20 g/100g Aerosol Topical 8.2 % w/w Solution Topical 0.1 mg/1mL Solution Topical 10 g/100mL Solution Topical 14 mg/100mL Solution Topical 14 g/100mL Liquid Topical 20 % Cream Topical 200 mg/1mL Solution Topical 200 mg/1mL Liquid Topical 18 % Stick Topical 18 g / 100 g Aerosol, spray Topical 0.24 g/1g Solution Topical 36 mL/65mL Aerosol Topical 12 % Aerosol, spray Topical 23.5 g/100g Aerosol, spray Topical 24.1 g/100g Aerosol, spray Topical 24.5 g/100g Lotion Topical 176 mg / mL Cream Topical 160 mg/1g Aerosol Topical 8.2 % Aerosol Topical 9.5 % Aerosol Topical 250 mg/1g Aerosol Topical 200 mg/1g Aerosol, spray Topical 200 mg/1g Cream Topical 11.4 g/57g Cream Topical 28 g/100g Emulsion Topical 280 mL/1000mL Liquid Topical 0.1128 g/1mL Stick Topical 25 g/100g Stick Topical 50 mL/50mL Liquid Topical 25 g/100mL Stick Topical 25 g/100mL Liquid Topical 50 g/100mL Liquid Topical 25 g/50mL Stick Topical 15 g / 100 g Stick Topical 17.6 g/100g Stick Topical 20 g/100g Liquid Topical 22 g/100mL Stick Topical 22 g/100mL Liquid Topical 22 mL/100mL Aerosol Topical 12 g/100g Aerosol Topical 10 g/100g Aerosol Topical Cream Topical 19 % Stick Topical 0.22 g/1g Stick Topical 220 mg/1g Stick Topical 11.4 g/57g Liquid Topical 190 mg/1mL Aerosol, spray Topical 0.194 g/1g Stick Topical 290.25 mg/1mL Spray Topical 15 g/100mL Stick Topical 12.3 g/12.3mL Cream Topical 11 g/57g Cream Topical 20 g/100g Liquid Topical 20 g/100g Liquid Topical 20 mg/100mL Liquid Topical 10 g/100g Liquid Topical 8 g/100g - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Liquid
- Experimental Properties
Property Value Source water solubility Soluble MSDS - Predicted Properties
Property Value Source Water Solubility 451.0 mg/mL ALOGPS logP -0.32 ALOGPS logP -0.65 Chemaxon logS 0.67 ALOGPS pKa (Strongest Acidic) 15.7 Chemaxon pKa (Strongest Basic) -1.8 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 25.3 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 3.7 m3·mol-1 Chemaxon Polarizability 1.51 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at April 06, 2016 22:31 / Updated at March 22, 2023 23:54