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Nifedipine Action Pathway
smpdb.ca/view/SMP0000379Drug actionNifedipine binds the major channel in muscle cells: L-type calcium channels. … Lack of initial influx of calcium can also reduce the level of contractile activity of muscle cells and results in vasodilation, which ultimately lead to overall decresing in blood pressure.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Nimodipine Action Pathway
smpdb.ca/view/SMP0000380Drug actionNimodipine binds the major channel in muscle cells: L-type calcium channels. … Compared to other DHP CCBs, nimodipine is more active in the cerebral vasculature than in the periphery. This may be due to its high lipophilicity and ability to penetrate the blood brain barrier.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Nisoldipine Action Pathway
smpdb.ca/view/SMP0000381Drug actionNisoldipine binds the major channel in muscle cells: L-type calcium channels. … Lack of initial influx of calcium can also reduce the level of contractile activity of muscle cells and results in vasodilation, which ultimately lead to overall decresing in blood pressure.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Carteolol Action Pathway
smpdb.ca/view/SMP0000658Drug actionCarteolol (also known as Cartrol or Ocupress) is a selective β1 adrenergic receptor antagonist (beta blocker), which can be used for treatment of high blood pressure (hypertension) and irregular heartbeats (arrhythmias). Carteolol a...
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Timolol Action Pathway
smpdb.ca/view/SMP0000659Drug actionThis, paired with the calcium activating a series of troponin enzymes that activate tropomyosin enzymes in the striated muscle, results in a muscle contraction. … The calcium and calmodulin then activate myosin light chain kinase, which is located in the smooth vascular muscle.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Dobutamine Action Pathway
smpdb.ca/view/SMP0000662Drug actionDobutamine is a type of medication that can be used for treating heart failure and cardiogenic shock. Dobutamine can bind to beta-1 adrenergic receptor on the heart cell which lead to mild chronotropic, arrhythmogenic, hypertensive and v...
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Levobunolol Action Pathway
smpdb.ca/view/SMP0000666Drug actionLevobunolol bind to beta1-adrenergic and beta2-adrenergic receptors in heart and vascular smooth muscle to block the binding of other adrenergic neurotransmitters such as norepinephrine, which lead to
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Metipranolol Action Pathway
smpdb.ca/view/SMP0000667Drug actionMetipranolol binds to beta1-adrenergic and beta2-adrenergic receptors in heart and vascular smooth muscle.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Practolol Action Pathway
smpdb.ca/view/SMP0000669Drug actionPractolol can also bind beta-2 adrenergic receptors in juxtaglomerular apparatus and bronchiole smooth muscle. … In bronchiole smooth muscle, binding of practolol to beta-2 adrenergic receptors can also prevent vasoconstriction.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126428Drug actionVerapamil's mechanism of action in the treatment of cluster headaches is unclear, but is thought to be involved with its effect on calcium channels. … Verapamil, known as the brand names Calan, Isoptin, Tarka, and Verelan, is a non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2