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Ripretinib
go.drugbank.com/drugs/DB14840ApprovedInvestigational[L13769] It is the first drug approved as a fourth-line therapy in the specific setting of prior treatment with a minimum of 3 other kinase inhibitors.[L13778] … Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA on May 15, 2020.
Categories: MATE 1 Inhibitors, P-glycoprotein inhibitorsInositol Metabolism
smpdb.ca/view/SMP0000011MetabolicInositol is abundant in many commonly consumed foods such as bran-rich cereals, beans, nuts, and fruit (particularly cantaloupe, melons, and oranges). … The carbocyclic polyol inositol (otherwise known as myo-inositol) has a significant role in physiological systems as many secondary eukaryotic messengers derive their structure from inositol.
Drugs: ATP · Calcium · Magnesium cation · Iron · 1D-myo-inositol 1,3,4-trisphosphate · Pyrophosphoric acid +1 moreEnzymes: Activating molecule in BECN1-regulated autophagy protein 1Pectin
go.drugbank.com/drugs/DB11158ApprovedInvestigationalVet approvedPectin is a heteropolysaccharide commercially derived from the cell wall of higher plants.[A32327] It is composed of partially methylated polygalacturonic acid units linked in the positions 1-4. … [L1961] The carboxylic group of the constituents of pectin can exist in the form of esters, free acids, ammonium, potassium or sodium salts or as acid amides.
Mixtures: Benylin DM With Pectin Freezer Pops, LEOLIN-P®Categories: Compounds used in a research, industrial, or household settingDihydrocodeine
go.drugbank.com/drugs/DB01551ApprovedIllicitIt is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more effective antitussive agent to help reduce the spread of airborne infectious diseases such as tuburculosis … It was marketed in 1911.
Mixtures: J-cof Dhc, J-max DhcCategories: Heterocyclic Compounds with 4 or More Rings, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromePimozide
go.drugbank.com/drugs/DB01100ApprovedA diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. … Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
Categories: Dopamine D2 Receptor Antagonists, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexProducts: พีไซด์ 4, NOROFREN 2 MG TABLET, 10 ADETT-Cell/Histiocyte-Rich Large B-Cell Lymphoma
go.drugbank.com/conditions/DBCOND0082251Drugs: Polatuzumab vedotinSynonyms: Malignant lymphoma, large B-cell, diffuse, no ICD-O subtypeDaclatasvir
go.drugbank.com/drugs/DB09102ApprovedInvestigationalWithdrawnThe same dosing regimen can be used as first-line therapy in patients with genotype 3 without cirrhosis and second-line therapy in genotype 3 patients with compensated cirrhosis. … According to 2017 American Association for the Study of Liver Diseases (AASLD), 60mg of daclatasvir is recommended with 400mg [DB08934] for genotype 1a/b patients with or without cirrhosis as second-line
Categories: Antivirals for treatment of HCV infections, P-glycoprotein inhibitorsProducts: I-HEP CLASTAVIR 30, I-HEP CLASTAVIR 60Ropeginterferon alfa-2b
go.drugbank.com/drugs/DB15119ApprovedInvestigational[A242005] Ropeginterferon alfa-2b is a next-generation mono-pegylated type I interferon produced from proline-IFN-α-2b in _Escherichia coli_ that has high tolerability and a long half-life. … [A242015, L39170] Ropeginterferon alfa-2b has shown efficacy in PV in _in vitro_ and _in vivo_ models and clinical trials.
Categories: Interferon Type I, Cytochrome P-450 CYP1A2 InhibitorsSynonyms: PEG-P-IFN-alfa-2b, PEG-P-IFN-alpha-2bTegafur-uracil
go.drugbank.com/drugs/DB09327ApprovedTegafur-uracil is an anti-tumor compound containing tegafur (1-(2-tetrahydrofuryl)-5-fluorouracil) and uracil in a molar ratio of 1:4. … It was developed as an anti-cancer therapy by Taiho Pharmaceutical Co Ltd.[A32073] It is approved in different countries but it is not yet approved by the FDA, Health Canada or EMA.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 SubstratesMilsaperidone
go.drugbank.com/drugs/DB24348ApprovedInvestigationalMilsaperidone is an atypical antipsychotic agent that rapidly interconverts to [iloperidone] in vivo. … [L56056] On February 20, 2026, milsaperidone was approved by the FDA for the treatment of Bipolar I Disorder and schizophrenia.[L56059]
Synonyms: (S)-Hydroxy iloperidoneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates