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Ergometrine
go.drugbank.com/drugs/DB01253ApprovedInvestigationalAn ergot alkaloid with uterine and vascular smooth muscle contractile properties.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesLabetalol
go.drugbank.com/drugs/DB00598ApprovedInvestigational[L7730] Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984.[L7724] … Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsProducts: LABLOL 100 MG/20 ML IV ENJEKSİYONLUK ÇÖZELTİ, 5 ADETDemeclocycline
go.drugbank.com/drugs/DB00618ApprovedA tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Fluoride ion F-18
go.drugbank.com/drugs/DB09398ApprovedInvestigationalSodium Fluoride F 18 Injection is a positron emitting radiopharmaceutical, no-carrier added.
Products: MON.NAF (18F) 250 MBQ/ML IV ENJEKSİYONLUK ÇÖZELTİ İÇEREN FLAKON, 1 ADETBismuth subsalicylate
go.drugbank.com/drugs/DB01294ApprovedVet approvedBismuth subsalicylate is an antacid and anti-diarrheal agent. … [A230728] It is an active ingredient found in Pepto-Bismol, a common over-the-counter medication that is used to temporarily treat discomforts of the stomach and gastrointestinal tract.
Erlotinib
go.drugbank.com/drugs/DB00530ApprovedInvestigationalRecent studies demonstrate that erlotinib is also a potent inhibitor of JAK2V617F, which is a mutant form of tyrosine kinase JAK2 found in most patients with polycythemia vera (PV) and a substantial proportion … This finding introduces the potential use of erlotinib in the treatment of JAK2V617F-positive PV and other myeloproliferative disorders.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexCalcitriol
go.drugbank.com/drugs/DB00136ApprovedInvestigationalNutraceuticala natural ligand [A175615]. … Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersProducts: CALCIJEX 1 MCG/ML IV AMPUL, 25 ADET, CALCIJEX 2 MCG/ML IV AMPUL, 25 ADETPrademagene zamikeracel
go.drugbank.com/drugs/DB17895ApprovedInvestigational[L53008] COL7A1 encodes type VII collagen (C7), which is a major component of anchoring fibrils (AF) that are critical for dermal-epidermal cohesion. … [L53013] It was granted an Orphan Drug designation by the EMA.[A273833]
Pitavastatin
go.drugbank.com/drugs/DB08860ApprovedInvestigationalas well as the need for surgical revascularization or angioplasty following a heart attack. … Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications.
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesRurioctocog alfa pegol
go.drugbank.com/drugs/DB16007ApprovedInvestigationalFactor VIII is an essential protein involved in normal blood clotting; thus, a deficient level of functional factor VIII is associated with an elevated risk for excessive bleeding caused by spontaneous … [L40119] Rurioctocog alfa pegol is a covalent conjugate of [octocog alfa], which is a recombinant factor VIII produced by recombinant DNA technology from a Chinese hamster ovary cell line.