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Displaying results 2501 - 2510 of 10000 in total
  1. Drug

    Zanubrutinib

    go.drugbank.com/drugs/DB15035
    ApprovedInvestigational

    L10166] which measures the proportion of patients in a trial whose tumour is entirely or partially destroyed by a drug. … [A187967] BTK is an enzyme that plays a role in oncogenic signalling pathways, promoting the survival and proliferation of malignant B cells.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic IndexProducts: BRUKINSA 80 mg capsules
  2. Drug

    Calcifediol

    go.drugbank.com/drugs/DB00146
    ApprovedInvestigationalNutraceutical

    It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients.

    Mixtures: HEPATAMINE %8 500 ML(SETLI), HEPATAMINE %8 500 ML(SETSIZ)Categories: Vitamin D and Analogues
  3. Drug

    Sulfadiazine

    go.drugbank.com/drugs/DB00359
    ApprovedInvestigationalVet approved

    One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.

    Synonyms: N(1)-2-Pyrimidylsulfanilamide, N(1)-2-PyrimidinylsulfanilamideMixtures: TMP/S-400 Medicated Premix Powder, SUFATRIM 48%w/w Premix
  4. Drug

    Pentastarch

    go.drugbank.com/drugs/DB09111
    ApprovedWithdrawn

    When administered, pentastarch remains mainly in the circulatory system and hence, it is considered a plasma expander. … Pentastarch is an artificial colloid (hydroxyethyl starch derivative). Pentastarch is characterized by presenting five hydroxyethyl groups, which signifies an approximate 50% hydroxyethylation.

    Categories: Compounds used in a research, industrial, or household settingProducts: HESTAR-200
  5. Target

    Potassium voltage-gated channel subfamily A member 1

    go.drugbank.com/bio_entities/BE0000781
    TargetHumans

    Plays a role in the reabsorption of Mg(2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (PubMed:19307729, PubMed:23903368 … Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception

    Polypeptides: Potassium voltage-gated channel subfamily A member 1
  6. Target

    HLA class I histocompatibility antigen, A alpha chain

    go.drugbank.com/bio_entities/BE0003483
    TargetHumans

    In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive

    Polypeptides: HLA class I histocompatibility antigen, A alpha chainSynonyms: HLA-A, MHC class I antigen A*3
  7. Target

    Potassium voltage-gated channel subfamily A member 7

    go.drugbank.com/bio_entities/BE0004719
    TargetHumans

    Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with

    Polypeptides: Potassium voltage-gated channel subfamily A member 7
  8. Target

    C-type lectin domain family 14 member A

    go.drugbank.com/bio_entities/BE0005467
    TargetHumans

    Polypeptides: C-type lectin domain family 14 member A
  9. Target

    Nuclear receptor subfamily 4 group A member 3

    go.drugbank.com/bio_entities/BE0008998
    TargetHumans

    During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). … Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part

    Polypeptides: Nuclear receptor subfamily 4 group A member 3
  10. Target

    Leukocyte immunoglobulin-like receptor subfamily A member 4

    go.drugbank.com/bio_entities/BE0013620
    TargetHumans

    production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a … Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354

    Polypeptides: Leukocyte immunoglobulin-like receptor subfamily A member 4