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Displaying results 2501 - 2510 of 10000 in total
  1. Drug

    Centanafadine

    go.drugbank.com/drugs/DB14841
    ApprovedInvestigational

    [L63934] The FDA approved centanafadine on July 24, 2026, for the treatment of ADHD in adults and pediatric patients 6 years of age and older weighing at least 20 kg; use is not recommended below that … [L63806] Its mechanism in ADHD is unclear, but its efficacy may be mediated by this triple reuptake inhibition, which increases the availability of all three neurotransmitters in pathways involved in attention

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
  2. Drug

    Lotilaner

    go.drugbank.com/drugs/DB17992
    ApprovedInvestigationalVet approved

    [A260746, L47556] Lotilaner consists of two enantiomers: the S-enantiomer is active _in vivo_, while the R-enantiomer is reported to exhibit low biological activity. … [L47546] Lotilaner has largely been used for veterinary uses as an antiparasitic agent to treat flea and tick infestations in animals.

    Synonyms: 2-thiophenecarboxamide, 5-((5s)-4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl)-3-methyl-n-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-, 3-methyi-n-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-5-((55)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl)thiophene-2-carboxamide
  3. Indication

    Toxic encephalopathy

    go.drugbank.com/conditions/DBCOND0014955
    Drugs: Edetic acid
    Synonyms: Toxic encephalitis due to lead, Toxic encephalopathy due to lead (disorder)
  4. Drug

    Vorasidenib

    go.drugbank.com/drugs/DB17097
    ApprovedInvestigational

    [A264209] It works by suppressing the levels of D-2-hydroxyglutarate (2-HG), an oncometabolite produced by mutant IDH1 and IDH2 isoforms. … [L51139] Vorasidenib displayed improved brain penetration and higher drug exposure compared to other IDH inhibitors such as [ivosidenib] and [enasidenib].

    Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 Substrates
  5. Indication

    Diabetic Cataract

    go.drugbank.com/conditions/DBCOND0136869
    Drugs: Bendazac
    Synonyms: Cataract of eye due to diabetes mellitus, Cataract of eye due to diabetes mellitus (disorder)
  6. Drug

    Capsaicin

    go.drugbank.com/drugs/DB06774
    ApprovedInvestigational

    Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements. Capsaicin is a naturally-occurr...

    Mixtures: THERMO SULIDIN %1 + %0,025 LIKIT JEL, 50 G, DicloHeal-60Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inducers
  7. Drug

    Amiloxate

    go.drugbank.com/drugs/DB11207
    Approved

    Amiloxate is an EMA-approved chemical UV-filter found in over-the-counter sunscreen products at concentrations up to 10%m [F35]. … It is often referred to as isoamyl 4-methoxycinnamate or isoamyl p-methoxycinnamate. Amiloxate is a cinnamic acid derivative with an anti-inflammatory activity [A32916].

    Mixtures: Laser Block 100 sunblock, Hansai Beestox Sun Cream SPF 50
  8. Indication

    Posttraumatic Osteoarthritis

    go.drugbank.com/conditions/DBCOND0086301
    Drugs: Cortisone acetate · Dexamethasone · Hydrocortisone · Methylprednisolone · Prednisolone
    Synonyms: Arthritis due to trauma, Arthritis secondary to trauma
  9. Indication

    Solar erythema

    go.drugbank.com/conditions/DBCOND0115935
    Drugs: Flumethasone · Neomycin
    Synonyms: Other skin changes due to chronic exposure to nonionizing radiation
  10. Indication

    Malignant Pleural Effusion

    go.drugbank.com/conditions/DBCOND0028841
    Drugs: Bleomycin · Talc
    Synonyms: Pleural effusion due to malignancy, Pleural effusion due to neoplastic disease (disorder)