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Olaparib
go.drugbank.com/drugs/DB09074ApprovedInvestigational[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell … [L41100, L40908, L43792] It was first approved by the FDA and EU in December 2014,[A246020] and by Health Canada in April 2016.[L42820]
Categories: MATE 2-K Inhibitors, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-oneGenistein
go.drugbank.com/drugs/DB01645InvestigationalExperimentally, it has been shown to induce G2 phase arrest in human and murine cell lines. Additionally, genistein has antihelmintic activity. … It has been determined to be the active ingredient in <I>Felmingia vestita</I>, which is a plant traditionally used against worms.
Mixtures: CALCIDAY G 1200 MG/800 IU/50 MG EFERVESAN TABLET, 45 ADET, CALCİDAY G 1000 MG/880 IU/50 MG EFERVESAN TABLET, 40 ADETCategories: Compounds used in a research, industrial, or household setting, P-glycoprotein inhibitorsLovastatin
go.drugbank.com/drugs/DB00227ApprovedInvestigational[A181087, A181406] Lovastatin and other drugs from the statin class of medications including [atorvastatin], [pravastatin], [rosuvastatin], [fluvastatin], and [simvastatin] are considered first-line … were found in clinical studies to result in a 45.8% to 54.6% decrease in LDL cholesterol levels, while lovastatin has been found to have an average decrease in LDL-C of 25-40%.
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsSynonyms: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate, 2β,6α-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactoneRurioctocog alfa pegol
go.drugbank.com/drugs/DB16007ApprovedInvestigational[L40119] Rurioctocog alfa pegol is a covalent conjugate of [octocog alfa], which is a recombinant factor VIII produced by recombinant DNA technology from a Chinese hamster ovary cell line. … Bleeding in joints is a common manifestation of hemophilia A, and bleeding episodes can be severe and life-threatening like intracranial hemorrhage.
Propiolactone
go.drugbank.com/drugs/DB09348ApprovedWithdrawnPropiolactone is a lactone compound with a four-membered ring. It is a colorless liquid with a pungent slightly sweet odor. … [A32144] It is currently FDA approved for its use as an indirect additive used in food contact substances. Propiolactone was first commercially available in the United States in 1958.[A32144]
Categories: Compounds used in a research, industrial, or household settingSynonyms: 3-propanolide, β-propiolactoneColchicine
go.drugbank.com/drugs/DB01394ApprovedInvestigationalColchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus."[A183611] Its use was first approved by the FDA in 1961. … [L8192] Colchicine is used in the treatment of gout flares and Familial Mediterranean fever,[L8138] and prevention of major cardiovascular events.
Categories: Preparations With No Effect on Uric Acid Metabolism, P-glycoprotein inducersProducts: L-CISIN, Colctab 1 mg TablettenMercaptopurine Metabolism Pathway
smpdb.ca/view/SMP0000609Drug metabolismnovo synthesis of purine nucleotides is inhibited by the methyl-thioinosine 5’-monophosphate metabolite, which inhibits amidophosphoribosyl-transferase, the enzyme that catalyzes one of the first steps in … The thioguanosine triphosphate metabolite also inhibits Ras-related C3 botulinum toxin substrate 1, a plasma membrane-associated small GTPase that regulates cellular processes, inducing apoptosis in activated
Oritavancin
go.drugbank.com/drugs/DB04911ApprovedInvestigational[A39384,A193482,L8492] On March 12, 2021 the FDA approved Kimyrsa, a complete course of therapy in a single, 1 hour 1200 mg infusion. … It boasts the option of single-dose administration and has been proven as non-inferior to a full course of [vancomycin] therapy.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP2C19 InhibitorsStreptococcus pneumoniae type 1 capsular polysaccharide antigen
go.drugbank.com/drugs/DB10319ApprovedInvestigationalIt is an active immunization for intramuscular or subcutaneous injection against pneumococcal disease such as pneumococcal pneumonia and pneumococcal bacteremia. … Streptococcus pneumoniae type 1 capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 1 of *Streptococcus pneumoniae*.
Mixtures: PNEUMOVAX 23 Injektionslösung in einer Fertigspritze, PNEUMOVAX 23 Injektionslösung in einer DurchstechflascheSynonyms: pneumococcal capsular polysaccharide type 1 vaccine, Streptococcus pneumoniae type 1 capsular polysaccharide antigenStreptococcus pneumoniae type 6b capsular polysaccharide antigen
go.drugbank.com/drugs/DB10324ApprovedInvestigationalIt is an active immunization for intramuscular or subcutaneous injection against pneumococcal disease such as pneumococcal pneumonia and pneumococcal bacteremia. … Streptococcus pneumoniae type 6b capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 6b of *Streptococcus pneumoniae*
Mixtures: PNEUMOVAX 23 Injektionslösung in einer Fertigspritze, PNEUMOVAX 23 Injektionslösung in einer Durchstechflasche