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Zytron
go.drugbank.com/drugs/DB11768ApprovedWithdrawnDMPA has been investigated for the prevention, treatment, and basic science of Weight and Microbiota. … Zytron (DMPA) is under investigation for the treatment and health services research of HIV, Lactation, Contraception, Postpartum Depression, and Immune Cells (Mucosal and Systemic).
Palivizumab
go.drugbank.com/drugs/DB00110ApprovedInvestigationalThe human heavy chain sequence was derived from the constant domains of human IgG1 and the variable framework regions of the VH genes Cor (1) and Cess (2). … Synagis is a composite of human (95%) and murine (5%) antibody sequences.
Categories: Antiinfectives for Systemic UseProducts: Synagis 100mg/ml solution for Injection, SYNAGIS SOLUTION FOR INJECTION 100MG/MLgamma-Hydroxybutyric acid
go.drugbank.com/drugs/DB01440ApprovedIllicitInvestigationalIt is used illegally under the street names Juice, Liquid Ecstasy or simply G, either as an intoxicant, or as a date rape drug. … Today Xyrem is a Schedule III drug; however GHB remains a Schedule I drug and the illicit use of Xyrem falls under penalties of Schedule I.
Degarelix
go.drugbank.com/drugs/DB06699ApprovedInvestigationalDegarelix is used for the treatment of advanced prostate cancer. … This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH) which ultimately causes testosterone suppression.
Products: Firmagon 120mg Powder and Solvent for Solution for Injection, Firmagon 80mg Powder and Solvent for Solution for InjectionEstradiol acetate
go.drugbank.com/drugs/DB13952ApprovedVet approvedEstradiol acetate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously within the human body. … As a pro-drug of estradiol, estradiol acetate therefore has the same downstream effects within the body through binding to the Estrogen Receptor (ER) including ERα and ERβ subtypes, which are located in
Thiotepa
go.drugbank.com/drugs/DB04572ApprovedInvestigationalN,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. … It is also used as conditioning for Bone marrow transplantation. Its main toxicity is myelosuppression.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: TEPADINA 15 mg powder for concentrate for solution for infusion, TEPADINA 100 mg powder for concentrate for solution for infusionTipranavir
go.drugbank.com/drugs/DB00932ApprovedInvestigationalTipranavir is a sulfonamide-containing dyhydropyrone and a nonpeptidic protease inhibitor that targets the HIV protease. Tipranavir and ritonavir are coadministered to treat HIV.
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseValoctocogene roxaparvovec
go.drugbank.com/drugs/DB15561ApprovedInvestigationalWithdrawn[L43282,A252807] Valoctocogene roxaparvovec was approved by EMA in September 2022 and is indicated for the treatment of severe hemophilia A. It is not approved for use in the United States. … [L43292] Hemophilia A treatments such as prophylactic regimens of exogenous factor VIII or [emicizumab] improve the clinical outcomes of patients but do not eliminate breakthrough bleeding.
Chlormadinone acetate
go.drugbank.com/drugs/DB15903ApprovedWithdrawnIn 1972, the FDA withdrew its approval for the use of chlormadinone acetate in all products. … Chlormadinone acetate is a progesterone derivative first synthesized in 1961.
Categories: Hormonal Contraceptives for Systemic UseSolriamfetol
go.drugbank.com/drugs/DB14754ApprovedInvestigationalwith narcolepsy or obstructive sleep apnea[FDA Label]. … Solriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated in treating daytime sleepiness associated
Categories: Psychostimulants, Agents Used for ADHD and Nootropics