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Amitriptyline
go.drugbank.com/drugs/DB00321ApprovedInvestigationalAmitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. … [A259342] Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties.[A174661]
Mixtures: Perphenazine and Amitriptyline Hydrochloride, Perphenazine and Amitriptyline HydrochlorideCategories: amitriptyline and psycholeptics, Tricyclics and Other Norepinephrine-reuptake InhibitorsChlordiazepoxide
go.drugbank.com/drugs/DB00475ApprovedIllicitAn anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
Mixtures: Nu-chlorax Capsules USP, Chlordiazepoxide and Amitriptyline HydrochlorideCategories: Hypnotics and Sedatives, Benzodiazepines and benzodiazepine derivativesIndomethacin
go.drugbank.com/drugs/DB00328ApprovedInvestigationalIndometacin was first discovered in 1963 and it was first approved for use in the U.S. by the Food and Drug Administration in 1965, [A486] along with other acetic acid derivatives such as [diclofenac] … Intravenous indometacin is administered to close a hemodynamically significant patent ductus arteriosus, as indicated by clinical evidence, in premature infants.
Categories: Antiinflammatory and Antirheumatic Products, Non-Steroids, indometacin and antiinfectivesInternational brands: Nu-IndoLarotrectinib
go.drugbank.com/drugs/DB14723ApprovedInvestigationalLarotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays … [L49821] Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation, which results in both the induction of cellular apoptosis and the inhibition
Categories: Antineoplastic and Immunomodulating AgentsProducts: VITRAKVI HARD CAPSULE 25MG, VITRAKVI ORAL SOLUTION 20MG/MLPindolol
go.drugbank.com/drugs/DB00960ApprovedInvestigational[L32353] Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. … Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension.
Categories: pindolol and other diuretics, Beta Blocking Agents, Non-SelectiveProducts: Nu-pindol Tab 10mg, Nu-pindol Tab 15mgFamotidine
go.drugbank.com/drugs/DB00927ApprovedInvestigationalIt is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. … disease, famotidine was about 20 to 50 times more potent at inhibiting gastric acid secretion than [cimetidine] and eight times more potent than [ranitidine] on a weight basis.
Synonyms: N-Sulfamoyl-3-((2-guanidinothiazol-4-yl)methylthio)propionamide, 3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamideMixtures: ETOFAM 400MG/20MG FİLM KAPLI TABLET, 20 ADET, ETOPLUS 400MG/8MG/20MG FİLM KAPLI TABLET, 14 ADETTopiramate
go.drugbank.com/drugs/DB00273ApprovedInvestigationalTopiramate is a anti-epileptic drug used to manage seizures and prevent migraines.[A175249] It was initially approved by the FDA in 1996. … [L10550] Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen.
Synonyms: 2,3:4,5-di-O-isopropylidene-β-D-fructopyranose sulfamate, 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamateMixtures: Phentermine and topiramate, Phentermine and topiramatePanobinostat
go.drugbank.com/drugs/DB06603ApprovedInvestigationalPanobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. … Panobinostat acts as a non-selective histone deacetylase inhibitor (pan-HDAC inhibitor) and it is the most potent DAC inhibiting agent available on the market.
Categories: Antineoplastic and Immunomodulating AgentsSynonyms: (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylamide, 2-PROPENAMIDE, N-HYDROXY-3-(4-(((2-(2-METHYL-1H-INDOL-3-YL)ETHYL)AMINO)METHYL)PHENYL)-, (2E)-Succinylcholine
go.drugbank.com/drugs/DB00202ApprovedInvestigationalIts rapid onset and offset, with effects beginning within 60 seconds of intravenous administration and lasting between four to six minutes, make succinylcholine particularly useful in the setting of short … Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups.
Synonyms: 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxy)]bis(N,N,N-trimethylethanaminium)Products: Anectine Nov, Anectine Inj 20mg/mlHydrocortisone
go.drugbank.com/drugs/DB00741ApprovedInvestigationalVet approvedHydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. … [L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.
Mixtures: DESYN-N, Neo-poly-bac HydroCategories: Alimentary Tract and Metabolism, Sex Hormones and Insulins