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Displaying results 251 - 260 of 4627 in total
  1. Drug

    Loratadine

    go.drugbank.com/drugs/DB00455
    ApprovedInvestigational

    Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st genera...

    Products: Quality Choice Childrens Allergy Relief
  2. Drug

    Protein C

    go.drugbank.com/drugs/DB11312
    ApprovedInvestigational

    It is converted by the thrombin/thrombomodulin-complex on the endothelial cell surface to Activated Protein C (APC). … APC exerts its effect by inactivating essential components of the coagulation cascade (specifically factors V and VIII), which leads to a decrease in thrombin formation, and therefore a reduction in clot

  3. Drug

    Flibanserin

    go.drugbank.com/drugs/DB04908
    ApprovedInvestigational

    It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder drug by Sprout Pharmaceuticals … Flibanserin's mechanism of action is attributed to its high affinity for 5-HTA1 and 5-HTA2 receptors, displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin

  4. Target

    Neurotensin receptor type 1

    go.drugbank.com/bio_entities/BE0013004
    TargetHumans

    G protein-coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:21725197, PubMed:23140271, PubMed:8381365). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling ...

    Synonyms: High-affinity levocabastine-insensitive neurotensin receptor
  5. Indication

    Prophylaxis of Thromboembolic event

    go.drugbank.com/conditions/DBCOND0024073
    Drugs: Bemiparin · Reviparin · Warfarin
  6. Drug

    Coagulation factor VII human

    go.drugbank.com/drugs/DB13150
    ApprovedInvestigational

    Coagulation factor VII is human serine protease type enzyme that is involved in the extrinsic coagulation cascade which results in blood clotting.

  7. Target

    Hepatoma-derived growth factor

    go.drugbank.com/bio_entities/BE0008975
    TargetHumans

    Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618)

    Synonyms: High mobility group protein 1-like 2
  8. Target

    Organic cation/carnitine transporter 2

    go.drugbank.com/bio_entities/BE0000106
    TargetTransporterHumans

    Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine.

    Synonyms: High-affinity sodium-dependent carnitine cotransporter
  9. Drug

    Anti-SARS-CoV-2 immunoglobulin

    go.drugbank.com/drugs/DB16360
    Investigational

    [L27521] Anti-coronavirus immunoglobulin is derived from [COVID-19 convalescent plasma](https://go.drugbank.com/drugs/DB15692) but contains more SARS-CoV-2 neutralizing antibodies than found in [convalescent

    Synonyms: COVID-HIG
  10. Drug

    Ibuprofen

    go.drugbank.com/drugs/DB01050
    ApprovedInvestigational

    Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ by the activity of the alpha-methylacyl-CoA racemase.

    Mixtures: Period Pills by BiikayProducts: Quality Choice Ibuprofen 200, Ibuprofen 24/7 Life by 7-Eleven