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Displaying results 2611 - 2620 of 10000 in total
  1. Drug

    Sotalol

    go.drugbank.com/drugs/DB00489
    ApprovedInvestigational

    [L6334] A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventricular arrhythmias and maintaining normal sinus rhythm … Sotalol is a methanesulfonanilide developed in 1960.[A178579] It was the first of the class III anti arrhythmic drugs.[A178579] Sotalol was first approved as an oral tablet on 30 October 1992.

    Synonyms: 4'-(1-hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide, β-cardoneCategories: Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index, sotalol and thiazides
  2. Drug

    Ceftriaxone

    go.drugbank.com/drugs/DB01212
    ApprovedInvestigational

    [A215582] It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges[A215582], eyes[A215647], and inner ear[A215627]. … Ceftriaxone is a commonly used antimicrobial due to its good activity against multi-drug resistant Enterobacteriaceae, its relatively safe adverse effect profile, and its long half-life which allows for

    Mixtures: CEFTRIAXONA 1000 MG + SULBACTAM 500 MG, CEF-3 INJECTION IM (1G)Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 2-Ring
  3. Drug

    Pregabalin

    go.drugbank.com/drugs/DB00230
    ApprovedInvestigational

    [A187190,L7066] Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release). … [A173995] It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions.

    Synonyms: (S)-3-Isobutyl GABA, 3-Isobutyl GABAMixtures: SYMRA PLUS B12 225 MG/1 MG SERT KAPSÜL, 56 ADET, PAGAMAX PLUS 75 MG/1 MG KAPSÜL ,60 KAPSÜL
  4. Drug

    Sitagliptin

    go.drugbank.com/drugs/DB01261
    ApprovedInvestigational

    Sitagliptin was granted FDA approval on October 16, 2006[L6061]. … Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256

    Mixtures: JANUMET 50 MG/500 MG FILM KAPLI TABLET, 56 ADET, JANUMET 50 MG/850 MG FILM KAPLI TABLET, 56 ADETCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 Substrates
  5. Drug

    Tetryzoline

    go.drugbank.com/drugs/DB06764
    Approved

    [A231769] Available since the 1950s, tetryzoline is a selective α<sub>1</sub>-receptor agonist [A231774] that is used as an ocular and nasal decongestant. … Tetryzoline, also known as tetrahydrozoline, is a derivative of imidazoline with central and peripheral alpha (α)-adrenergic properties.

    Synonyms: 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole, (RS)-2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazoleMixtures: EFEMOLINE 5 ML DAMLA, DG Health Sterile Advanced Relief Eye
  6. Drug

    Azelastine

    go.drugbank.com/drugs/DB00972
    ApprovedInvestigational

    allergic rhinitis in patients 6 years of age and older. … Azelastine, a phthalazine derivative, is an antihistamine available as an intranasal spray for the treatment of allergic and vasomotor rhinitis and as an ophthalmic solution for the treatment of allergic

    Synonyms: 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinoneMixtures: DYMİSTA 137 MCG + 50 MCG BURUN SPREYİ, SÜSPANSİYON, 23 G, DYMİSTA 137 MCG + 50 MCG BURUN SPREYİ, SÜSPANSİYON, 6,4 G
  7. Drug

    Aminophylline

    go.drugbank.com/drugs/DB01223
    ApprovedInvestigational

    Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. … Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator.

    Categories: Xanthines and Adrenergics, aminophylline and adrenergicsProducts: TECAR 240 MG/10 ML IV INFUZYONLUK COZELTI, 6 ADET, AMINOCARDOL 10 ML 240 MG 100 AMPUL
  8. Drug

    Betahistine

    go.drugbank.com/drugs/DB06698
    ApprovedInvestigational

    [A220333,L16403] Betahistine was first approved by the FDA in the 1970s but withdrawn within approximately 5 years due to a lack of evidence supporting its efficacy. … It has a significant impact on both the physical and social functioning of affected individuals.

    Synonyms: N-methyl-2-(2-pyridinyl)ethanamine, [2-(2-pyridyl)ethyl]methylamineCategories: Heterocyclic Compounds, 1-Ring
  9. Drug

    DPDPE

    go.drugbank.com/drugs/DB08861
    Experimental

    A heterodetic cyclic peptide that is a cyclic enkephalin analogue, having D-penicillaminyl residues located at positions 2 and 5, which form the heterocycle via a disulfide bond.

    Synonyms: L-tyrosyl-3-mercapto-D-valylglycyl-L-phenylalanyl-3-mercapto-D-valine, cyclic (2-5)-disulfide, (D-Pen2,D-Pen5)-EnkephalinCategories: Amino Acids, Peptides, and Proteins
  10. Drug

    Dimethyl fumarate

    go.drugbank.com/drugs/DB08908
    ApprovedInvestigational

    It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated … [L43752] Dimethyl fumarate is marketed under the brand name Tecfidera, and it was the third oral disease-modifying agent for multiple sclerosis approved by the FDA, following [fingolimod] and [teriflunomide

    Synonyms: (E)-But-2-enedioic acid dimethyl esterCategories: Antineoplastic and Immunomodulating Agents