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Mitoquinone
go.drugbank.com/drugs/DB05063Investigational-- where they accumulate up to a thousand fold. … Mitochondrial dysfunction also has been shown to represent an early critical event in the pathogenesis of the sporadic form of Parkinson's disease.
Categories: Enzymes and CoenzymesNuclear receptor subfamily 1 group I member 2
go.drugbank.com/bio_entities/BE0000956TargetHumansNuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. … Activated by a broad range of endogenous steroids (e.g. pregnenolone, progesterone) and xenobiotics, including the antibiotic rifampicin and certain plant-derived metabolites.
Synonyms: Steroid and xenobiotic receptorCatumaxomab
go.drugbank.com/drugs/DB06607ApprovedWithdrawnIt has affinity for T-cells, accessory immune cells, and cancer cells. … Catumaxumab was initially authorized for market by the European Medicines Agency in April 2009 for the treatment of malignant ascites [L1122].
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsTrypsin
go.drugbank.com/drugs/DB11237ApprovedInvestigationalVet approvedThis nucleophilic attack is facilitated by the catalytic triad consisting of histidine-57, aspartate-102, and serine-195. … Therapeutic forms of trypsin is obtained from purified extracts of porcine or bovine pancreas and is intended to aid in digestion when administered orally.
Categories: Enzymes and Coenzymes, Blood and Blood Forming OrgansBlack cohosh
go.drugbank.com/drugs/DB13975Approved[A32543] The American College of Obstetrics and Gynecology guidelines on the use of botanicals, such as black cohosh, for the management of menopausal symptoms the use of for up to six months, especially … [A32542] Results from studies suggest that C. racemosa possesses a central activity instead of a hormonal effect.
Categories: Herbs and Natural Products, Genito Urinary System and Sex HormonesAbametapir
go.drugbank.com/drugs/DB11932ApprovedThe necessity for follow-up treatment may lead to challenges with patient adherence, and resistance to agents like permethrin and [pyrethrins]/[piperonyl butoxide] may be significant in some areas. … [A216178] Abemetapir is an inhibitor of these metalloproteinase enzymes, and the first topical pediculicide to take advantage of this novel target.
Categories: Scabicides, Insecticides and Repellents, Antiparasitic Products, Insecticides and RepellentsFidaxomicin
go.drugbank.com/drugs/DB08874ApprovedInvestigational[A190492] The antibacterial activity of fidaxomicin is distinct from macrolides and rifamycins, as the bactericidal activity is time-dependent, and not concentration-dependent. … [L11575] Fidaxomicin is a naturally-occurring 18-member macrocycle derived from fermentation.
Categories: Alimentary Tract and MetabolismCrotalus scutulatus antivenin
go.drugbank.com/drugs/DB13891ApprovedCrotalus scutulatus antivenin is derived and purified immunoglobulin fragments obtained from other domestic animals such as sheep previously immunized with Crotalus scutulatus (also known as the _Mojave … The final purified antivenin product is obtained by mixing other different monospecific snake antivenins and isolating the antivenin of interest through fractionation and chromatography techniques.
Choline C 11
go.drugbank.com/drugs/DB09277Approved[A32041] It was developed by MCPRF and FDA first approved in September 2012.
Moxetumomab pasudotox
go.drugbank.com/drugs/DB12688ApprovedInvestigational[A38864] MxP appears as an improved form of BL22 by the mutation of the Fv region and the antibody phage-displayed. As well the residues SSY in the heavy chain are mutated to THW. … [A38864] It was developed by Astra Zeneca and FDA approved on September 13, 2018, after being granted the status of Fast Track, Priority Review and Orphan Drug designations.[L4568]
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating Agents