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Displaying results 2631 - 2640 of 10000 in total
  1. Drug

    4-hydroxybenzoyl-CoA

    go.drugbank.com/drugs/DB01652
    Experimental

    Categories: Thioesters of coenzyme A, Heterocyclic Compounds, 2-RingSynonyms: 4-hydroxybenzoyl coenzyme A, 4-hydroxybenzoyl-coenzyme A
  2. Drug

    Roflumilast

    go.drugbank.com/drugs/DB01656
    ApprovedInvestigational

    Roflumilast is a highly selective phosphodiesterase-4 (PDE4) inhibitor. … [A251385] PDE4 is a major cyclic-3',5′-adenosinemonophosphate (cyclic AMP, cAMP)-metabolizing enzyme [L37564] expressed on nearly all immune and pro-inflammatory cells, in addition to structural cells

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: DAXAS®
  3. Drug

    Methacrylyl-Coenzyme A

    go.drugbank.com/drugs/DB01675
    Experimental

    Categories: Heterocyclic Compounds, 2-RingSynonyms: Methacrylyl-Coenzyme A
  4. Drug

    Miravirsen

    go.drugbank.com/drugs/DB12851
    Investigational

    Miravirsen has been investigated for the treatment of Hepatitis C and Hepatitis C, Chronic.

  5. Drug

    Lutetium Lu 177 dotatate

    go.drugbank.com/drugs/DB13985
    ApprovedInvestigational

    In terms of biodistribution, Lutetium Lu 177 dotatate demonstrated a lower whole-body retention, indicating potentially lower risk for bone marrow toxicity [A31696]. … A 177Lu-labeled somatostatin analog peptide, Lutetium Lu 177 dotatate belongs to an emerging form of treatments called Peptide Receptor Radionuclide Therapy (PRRT), which involves targeting tumours with

    Categories: Compounds used in a research, industrial, or household settingSynonyms: Lutetium Lu 177 DOTA(0)-Tyr(3)-Octreotate, 177-Lu DOTA-0-Tyr3-Octreotate
  6. Drug

    Zalcitabine

    go.drugbank.com/drugs/DB00943
    ApprovedWithdrawn

    A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. … The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one, 2',3'-Dideoxycytidine
  7. Drug

    Desloratadine

    go.drugbank.com/drugs/DB00967
    ApprovedInvestigational

    Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action. … It is the active descarboethoxy metabolite of loratidine (a second generation histamine).

    Mixtures: DESLAIR® - D, DESLODEX ® D CÁPSULASCategories: P-glycoprotein inhibitors, Heterocyclic Compounds, 1-Ring
  8. Drug

    Selenium Sulfide

    go.drugbank.com/drugs/DB00971
    Approved

    Selenium Sulfide is the active ingredient often used in shampoos for the treatment of dandruff, seborrheic dermatitis and tinea capitis, a fungal infection that is primarily a disease of preadolescent … Selenium Sulfide is an antifungal agent as well as a cytostatic agent, slowing the growth of hyperproliferative cells in seborrhea.

    Products: Selsun Blue 2-in-1, Selsun Blue, 2-IN-1
  9. Drug

    Ezetimibe

    go.drugbank.com/drugs/DB00973
    ApprovedInvestigational

    Ezetimibe is a lipid-lowering compound that inhibits intestinal cholesterol and phytosterol absorption. … C1-Like 1 (NPC1L1), and is unique in that it does not affect the absorption of fat-soluble nutrients such as fat-soluble vitamins, triglycerides, or bile acids.

    Mixtures: TIAZOMET S®, TIAZOMET S®Categories: P-glycoprotein substrates, Cytochrome P-450 CYP2C8 Inhibitors
  10. Drug

    Telithromycin

    go.drugbank.com/drugs/DB00976
    Approved

    Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. … Binding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsProducts: KETEK ® 400 MG