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Nirmatrelvir
go.drugbank.com/drugs/DB16691ApprovedInvestigational[L46921] Paxlovid was approved for use in Canada in January 2022 for the treatment of adult patients with mild-moderate COVID-19 [L39544] and later granted conditional marketing authorization by the European … [L33359] Both drugs were inhibitors of SARS-CoV-2 3CL<sup>PRO</sup>, but nirmatrelvir has the advantage of being orally bioavailable.
Categories: nirmatrelvir and ritonavir, Amino Acids, Peptides, and ProteinsIL15-NK Cell
go.drugbank.com/drugs/DB15725InvestigationalIn particular, incubation with IL-15 allows NK cells to lyse a broad range of fresh and cultured tumor targets that the cell is not normally sensitive to. … Natural killer (NK) cells can be incubated with ‘feeder cells’ expressing certain cytokines prior to maturation to enhance their activity.
Synonyms: IL15-NK CellFecal microbiota
go.drugbank.com/drugs/DB17743ApprovedInvestigational[A259172] REBYOTA, a live fecal microbiota suspension for rectal use, was approved by the FDA in November 2022. … Recurrent CDI has a high risk of mortality and a high failure rate.
Olsalazine
go.drugbank.com/drugs/DB01250Approved[A257078] Olsalazine is an anti-inflammatory agent that works by inhibiting cyclooxygenase and lipoxygenase, subsequently reducing the production of pro-inflammatory factors like prostaglandin and leukotriene … [A257078] Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon.
Categories: Alimentary Tract and MetabolismFloxuridine
go.drugbank.com/drugs/DB00322ApprovedInvestigationalIt has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. … An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution.
Categories: Antineoplastic and Immunomodulating Agents, Nucleic Acids, Nucleotides, and NucleosidesOrnithine
go.drugbank.com/drugs/DB00129ApprovedInvestigationalNutraceuticalProduced during the urea cycle, ornithine is an amino acid produced from the splitting off of urea from arginine. … L-Ornithine allows for the disposal of excess nitrogen and acts as a precursor of citrulline and arginine.
Categories: Bile and Liver Therapy, Alimentary Tract and MetabolismPalovarotene
go.drugbank.com/drugs/DB05467Approved[L39990,L40020] It has been granted rare pediatric disease and breakthrough therapy designations from the US FDA, although a previously submitted NDA was withdrawn in August 2021 pending the resubmission … [A244920] The ossification occurring as a result of FOP is insidious and cumulative and is provoked during flare-ups or in response to injury.
Sleeping Disorders
go.drugbank.com/conditions/DBCOND0148601Synonyms: Sleep disorders and disturbancesUmbralisib
go.drugbank.com/drugs/DB14989ApprovedInvestigationalWithdrawn[A229363] Follicular lymphoma is also treated with rituximab and other chemotherapeutic agents, but may show similar progression. … from clinical trials.
Categories: Antineoplastic and Immunomodulating AgentsLumacaftor
go.drugbank.com/drugs/DB09280ApprovedInvestigational[A20343] Improvements in lung function (ppFEV1) were found to be statistically significant, but minimal, with only a 2.6-3.0% change from baseline with more than 70% of patients failing to achieve an absolute … Ivacaftor is manufactured and distributed by Vertex Pharmaceuticals.
Categories: ivacaftor and lumacaftor