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Displaying results 2671 - 2680 of 3601 in total
  1. Drug

    Capravirine

    go.drugbank.com/drugs/DB08502
    Investigational

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Substrates
  2. Drug

    Isoliquiritigenin

    go.drugbank.com/drugs/DB03285
    Experimental

    Isoliquiritigenin is a precursor to several flavonones in many plants.

    Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 Inhibitors
  3. Drug

    Azidocillin

    go.drugbank.com/drugs/DB08795
    Experimental

    Azidocillin is a penicillin antibiotic similir to ampicillin.

  4. Drug

    Sulfamoxole

    go.drugbank.com/drugs/DB08798
    Experimental

    Sulfamoxole is an antibacterial in the sulfonamide class.

    Synonyms: 2-(p-Aminobenzenesulfonamido)-4,5-dimethyloxazole, 2-(p-Aminobenzolsulfonamido)-4,5-dimethyloxazolCategories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme Inhibitors
  5. Drug

    Tofisopam

    go.drugbank.com/drugs/DB08811
    Investigational

    In contrast to classical 1,4-benzodiazepines, the compound does not bind to the benzodiazepine binding site of the gamma-aminobutyric acid receptor and its psychopharmacological profile differs from such

    Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 Inhibitors
  6. Drug

    Vismodegib

    go.drugbank.com/drugs/DB08828
    ApprovedInvestigational

    Vismodegib is an orally active small molecule that inhibits the hedgehog signaling pathway by binding to and inhibiting the transmembrane protein smoothened homologue (SMO). It was discovered by high-throughput screening of a library of ...

    Categories: Smoothened Receptor Antagonists, P-glycoprotein substrates
  7. Drug

    Boceprevir

    go.drugbank.com/drugs/DB08873
    ApprovedWithdrawn

    Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is...

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  8. Drug

    Carfilzomib

    go.drugbank.com/drugs/DB08889
    ApprovedInvestigational

    Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treat...

    Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  9. Drug

    Perospirone

    go.drugbank.com/drugs/DB08922
    Investigational

    Perospirone is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist. Dainippon...

    Categories: Dopamine D2 Receptor Antagonists, Cytochrome P-450 Substrates
  10. Drug

    Macitentan

    go.drugbank.com/drugs/DB08932
    ApprovedInvestigational

    Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH).[L35890] It was first approved by the FDA in 2013.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Substrates