Isoliquiritigenin

DB03285ExperimentalSmall molecule

Isoliquiritigenin is a precursor to several flavonones in many plants.

Mechanism: Pharmacologically active on Aldo-keto reductase family 1 member B1, Cystic fibrosis transmembrane conductance regulator, and NACHT, LRR and PYD domains-containing protein 3
Curator reviewed
Formula / weight: C₁₅H₁₂O₄ · 256.2534 g/mol (avg)
Also known as: (E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-propenone · (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propene-1-one · 2',4,4'-Trihydroxychalcone · 4,2',4'-Trihydroxychalcone · trans-2',4,4'-trihydroxychalcone
Code names: GU-17

Resolves to

Compound

Structure

InChIKeyDXDRHHKMWQZJHT-FPYGCLRLSA-NSMILESOC1=CC=C(\C=C\C(=O)C2=C(O)C=C(O)C=C2)C=C1

Targets

What you can answer from here — as of August 31, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

10+ReferencesStructured and connected to the statements they support

Which drugs share a target with Isoliquiritigenin, and which of those have an active Phase 3 trial?

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