DB08795ExperimentalSmall molecule
Azidocillin is a penicillin antibiotic similir to ampicillin.
- Mechanism
- Curator reviewed
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Azidocillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Azidocillin interferes with an autolysin inhibitor.
- Primary indication
- For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptocCurator reviewed
- Formula / weight
- C16H17N5O4S · 375.402 g/mol (avg)
- Code names
- BRL-2534 · SPC-297-D
Resolves to
Clinical / RWD
Structure
InChIKey
ODFHGIPNGIAMDK-NJBDSQKTSA-NSMILES[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N=[N+]=[N-])C1=CC=CC=C1)C(O)=OTransporters
What you can answer from here — as of February 21, 2021
5Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
3TransportersSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Azidocillin, and which of those have an active Phase 3 trial?
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