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Tumor necrosis factor receptor superfamily member 18
go.drugbank.com/bio_entities/BE0010519TargetHumansReceptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death.
Polypeptides: Tumor necrosis factor receptor superfamily member 18Synonyms: Activation-inducible TNFR family receptorLow-density lipoprotein receptor-related protein 6
go.drugbank.com/bio_entities/BE0012061TargetHumansComponent of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (PubMed:11357136, PubMed:11448771
Polypeptides: Low-density lipoprotein receptor-related protein 6Tyrosine-protein phosphatase non-receptor type 2
go.drugbank.com/bio_entities/BE0012706TargetHumansMay also bind DNA … May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis.
Polypeptides: Tyrosine-protein phosphatase non-receptor type 2Tumor necrosis factor receptor superfamily member EDAR
go.drugbank.com/bio_entities/BE0021253TargetHumansReceptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death
Polypeptides: Tumor necrosis factor receptor superfamily member EDARSynonyms: EDA-A1 receptor, Ectodysplasin-A receptorT cell receptor beta variable 6-5
go.drugbank.com/bio_entities/BE0021562TargetHumansV region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).
Polypeptides: T cell receptor beta variable 6-5Tebipenem pivoxil
go.drugbank.com/drugs/DB16840Approved[L57979,L57980] It retains activity against many extended-spectrum beta-lactamase producers but not against organisms producing serine or metallo-carbapenemases. … [L57980] Tebipenem pivoxil is the first oral carbapenem approved in the United States, creating an outpatient option for patients who have limited or no alternative oral therapy.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseEthinylestradiol
go.drugbank.com/drugs/DB00977ApprovedInvestigational[A191107] It was developed in an effort to create an estrogen with greater oral bioavailability. … [A191107] These properties were achieved by the substitution of an ethinyl group at carbon 17 of [estradiol].[A191107] Ethinylestradiol soon replaced [mestranol] in contraceptive pills.
Mixtures: Min-ovral 21, Min-ovral 28Categories: Hormonal Contraceptives for Systemic Use, P-glycoprotein substratesPhentolamine
go.drugbank.com/drugs/DB00692ApprovedInvestigationalWhile initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral
Categories: Adrenergic alpha-1 Receptor AntagonistsSynonyms: 2-(N-(m-hydroxyphenyl)-p-toluidinomethyl)imidazolineProtriptyline
go.drugbank.com/drugs/DB00344ApprovedSee toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression. … They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation.
Categories: P-glycoprotein inhibitors, Antidepressive Agents Indicated for DepressionAzficel-T
go.drugbank.com/drugs/DB11051ApprovedWithdrawnAzficel-T is an autologous cellular product composed of fibroblasts indicated for improvement of the appearance of moderate to severe nasolabial fold wrinkles in adults. … Azficel-T is marketed in the US as Laviv for intradermal injection.