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Xylometazoline
go.drugbank.com/drugs/DB06694Approved[A228508] Xylometazoline is available in over-the-counter (OTC) nasal sprays or drops to temporarily relieve nasal congestion due to cold, hay fever or other respiratory allergies. … In some countries, it is available as combination products with [ipratropium], [domiphen], or [dexpanthenol].
Mixtures: nasic pur Nasenspray für Kinder, nasic - Nasenspray für Kinder 5 mg/500 mgProducts: OLYNTH 0.05% N O KONSERVIE, OLYNTH 0.1% N O KONSERVIERCobimetinib
go.drugbank.com/drugs/DB05239ApprovedInvestigationalIt has been approved in Switzerland and the US, in combination with vemurafenib for the treatment of patients with unresectable or metastatic BRAF V600 mutation-positive melanoma. … Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction
Ethynodiol diacetate
go.drugbank.com/drugs/DB00823ApprovedAlthough etynodiol or ethynodiol are sometimes used as a synonym for ethynodiol diacetate, what is usually being referred to is actually ethynodiol diacetate and not ethynodiol (which is a separate drug … A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
Categories: Hormonal Contraceptives for Systemic UseSynonyms: 3β,17β-Diacetoxy-19-nor-17α-pregn-4-en-20-yne, 19-Nor-17α-pregn-4-en-20-yne-3β,17-diol diacetateLevomilnacipran
go.drugbank.com/drugs/DB08918ApprovedInvestigational[L47956] While levomilnacipran was previously investigated and proposed as a potential treatment for stroke in Europe, the EMA decided against this use.[L48011] … [L47946] First approved by the FDA on July 25, 2013, levomilnacipran is used to treat major depressive disorder in adults.
Categories: Antidepressive Agents Indicated for Depression, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeSynonyms: CYCLOPROPANECARBOXAMIDE, 2-(AMINOMETHYL)-N,N-DIETHYL-1-PHENYL-, (1S,2R)-Isotretinoin
go.drugbank.com/drugs/DB00982ApprovedInvestigational[L6579] The first isotretinoin-containing product was FDA approved on 7 May 1982.[L6574] … [L6574] Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.
Categories: Retinoids for Topical Use in Acne, Retinoids for Treatment of AcneSynonyms: 13-RA, cis-RASelpercatinib
go.drugbank.com/drugs/DB15685ApprovedInvestigational[A202049, A202055, A202052, L13604] Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific … Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.
Calaspargase pegol
go.drugbank.com/drugs/DB14730ApprovedInvestigationalCalaspargase pegol, by _Shire_ pharmaceuticals, was approved by the FDA on December 20, 2018 for acute lymphoblastic anemia (ALL) [L4890]. … Calaspargase pegol, also known as _asparlas_, is an asparagine specific enzyme which is indicated as a part of a multi-agent chemotherapy regimen for the treatment of ALL [L4890].
Categories: Compounds used in a research, industrial, or household settingPregabalin
go.drugbank.com/drugs/DB00230ApprovedInvestigational[L1006,L7066] It may have dependence liability if misused but the risk appears to be highest in patients with current or past substance use disorders.[A31161] … Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter.
Products: Nb-pregabalin, PREGABALINA CÁPSULAS X 300 MGAjmaline
go.drugbank.com/drugs/DB01426ApprovedWithdrawnIt has also been used for many years as a drug to challenge the conduction system of the heart in cases of bundle branch block and syncope. … In these cases, abnormal prolongation of the HV interval has been taken as a proof for infrahisian conduction defects tributary for permanent pacemaker implantation.
Categories: Antiarrhythmics, Class I, Antiarrhythmics, Class IaTiopronin
go.drugbank.com/drugs/DB06823ApprovedIt has been investigated for use in the treatment of arthritis and as a neuroprotective agent in aneurysmal subarachnoid hemorrhage. … Patients with cystinuria excrete high levels of cystine in their urine and are at risk for kidney stone formation.
Categories: N-substituted GlycinesInternational brands: Kai Na