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Daprodustat
go.drugbank.com/drugs/DB11682ApprovedInvestigationalanemia of CKD but not for non-dialysis patients with anemia of CKD. … [L43857] On February 1, 2023, daprodustat was fully approved by the FDA as the first oral treatment for anemia caused by chronic kidney disease in patients on dialysis.
Categories: Blood and Blood Forming Organs, Amino Acids, Peptides, and ProteinsSynonyms: Glycine, N-((1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl)-Troglitazone
go.drugbank.com/drugs/DB00197ApprovedWithdrawnTroglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone].
Categories: Alimentary Tract and Metabolism, Drugs Used in DiabetesElivaldogene autotemcel
go.drugbank.com/drugs/DB16746ApprovedIt is used to provide functional copies of human adrenoleukodystrophy protein (ALDP) in patients with adrenoleukodystrophy,[L39491] an X-linked genetic disorder characterized by missing or non-functional … Without sufficient levels of functional ALDP, VLCFAs accumulate in the body leading to inflammation and destruction of myelin, which is an insulating layer and essential component of nerves.
Categories: Cellular and Gene Therapy, Alimentary Tract and MetabolismHaemorrhoids
go.drugbank.com/conditions/DBCOND0010582Drugs: Aluminum subacetate · Balsam of Peru · Benzalkonium · Benzocaine · Bismuth oxide · Bismuth subgallate +27 moreSynonyms: Hemorrhoids and perianal venous thrombosisVomiting, Postoperative
go.drugbank.com/conditions/DBCOND0089766Drugs: DiphenidolSynonyms: Postoperative Nausea and VomitingMagnesium silicate
go.drugbank.com/drugs/DB13249ApprovedWithdrawnThe molecular formula can be expressed more clearly as MgSiO3.xH2O.[T186] It is known as talc and it presents many uses in the cosmetic industry, food industry and pharmaceutical industry. … Magnesium silicate is a compound of magnesium oxide and silicon. It is the magnesium salt of silicic acid containing an unspecified amount of water.
Categories: Alimentary Tract and Metabolism, Aluminum and magnesium containing antacidsAnakinra
go.drugbank.com/drugs/DB00026ApprovedInvestigational[L35415] Since IL-1 has an important role in inflammation and immunological responses, anakinra is also used for the off-label treatment of inflammatory diseases. … Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsSynonyms: IL-1RAPegloticase
go.drugbank.com/drugs/DB09208ApprovedInvestigational[L42425] Pegloticase was approved by the FDA in 2014, and in 2022, the drug label included the co-administration of pegloticase and methotrexate.[L42425] … Therefore therapeutic drug levels can be maintained with infrequent and relatively low pegloticase doses.[A249980] The PEG group also gives pegloticase a lower potential to induce an immune response.
Categories: Enzymes and Coenzymes, Compounds used in a research, industrial, or household settingChymotrypsin
go.drugbank.com/drugs/DB09375ApprovedInvestigationalVet approvedWithdrawnChymotrypsin is the most abundant pancreatic proteases that represent up to 10-20% of the total protein synthesized by the exocrine pancreas [A32637]. … It is a serine protease synthesized in the pancreas and is a vital component in the pancreatic juice.
Categories: Enzymes and Coenzymes, Blood and Blood Forming OrgansPelvic Inflammatory Disease (PID)
go.drugbank.com/conditions/DBCOND0058270Synonyms: Inflammatory disease of female pelvic organs AND/OR tissues, Inflammatory disease of female pelvic organs and tissues, NOS