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Displaying results 2741 - 2750 of 10000 in total
  1. Drug

    Cefroxadine

    go.drugbank.com/drugs/DB11367
    ApprovedWithdrawn

    It was used in Italy but has since been withdrawn. … Cefroxadine is an orally available cephalosporin antibiotic. As part of its drug class, it shares structural properties to [cefalexin] as well as its activity spectrum.

  2. Drug

    Lonidamine

    go.drugbank.com/drugs/DB06266
    Investigational

    In such way LND could impair energy-requiring processes, as recovery from potentially lethal damage, induced by radiation treatment and by some cytotoxic drugs. … Lonidamine (LND) is a drug that interferes with energy metabolism of cancer cells, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).

    Categories: Antineoplastic and Immunomodulating Agents
  3. Drug

    Technetium Tc-99m disofenin

    go.drugbank.com/drugs/DB09164
    ApprovedWithdrawn

    for liver uptake) as are other tracers from the iminodiacetic acid. … It is well suited for both planar and single photon tomographic scintigraphy to quantitatively measure the function of liver, gallbladder and bile ducts and detect any anatomical changes in the hepatobliary

    Categories: Indicators and Reagents, Amino Acids, Peptides, and Proteins
  4. Target

    Potassium-transporting ATPase ATP-binding subunit

    go.drugbank.com/bio_entities/BE0003296
    TargetEscherichia coli (strain K12)

    This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm (PubMed:16354672, PubMed:30478378, PubMed:34272288).

    Synonyms: Potassium-binding and translocating subunit B
  5. Target

    Myosin light chain 6B

    go.drugbank.com/bio_entities/BE0004292
    TargetHumans

    Regulatory light chain of myosin. Does not bind calcium

    Synonyms: Smooth muscle and nonmuscle myosin light chain alkali 6B
  6. Target

    Ephrin type-A receptor 8

    go.drugbank.com/bio_entities/BE0009440
    TargetHumans

    With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. … The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation.

    Synonyms: EPH- and ELK-related kinase
  7. Drug

    Technetium Tc-99m sulfur colloid

    go.drugbank.com/drugs/DB09397
    Approved

    (intraperitoneal injection), is taken up by reticulocytes (intravenous injection), or enters the gastroesphageal tract (oral administration). … studies of esophageal transit and gastroesophageal reflux.

    Categories: Indicators and Reagents, Hepatic and Reticulo Endothelial System
  8. Drug

    Estradiol cypionate

    go.drugbank.com/drugs/DB13954
    ApprovedVet approved

    Because of the difference in potency between estradiol and estrone, menopause (and a change in primary hormone from estradiol to estrone) is associated with a number of symptoms associated with this reduction … Esterification of estradiol aims to improve absorption and bioavailability after oral administration (such as with Estradiol Valerate) or to sustain release from depot intramuscular injections (such as

    Categories: Hormones, Hormone Substitutes, and Hormone Antagonists
  9. Drug

    Parethoxycaine

    go.drugbank.com/drugs/DB19380
    ApprovedWithdrawn

    Parethoxycaine is a local anesthetic that was previously approved in the US.

  10. Drug

    Tapinarof

    go.drugbank.com/drugs/DB06083
    ApprovedInvestigational

    [A248790] Tapinarof received initial approval from the FDA in 2022.[L41845]